Arch Clin Med Case Rep 2020; 4 (5): 797-812 DOI: 10.26502/acmcr.96550267 Archives of Clinical and Medical Case Reports 797 Review Article Imaging Manifestations of Soft Tissue Lymphoma Uma Debi MD * , Maoulik Kumar MD, Lokesh Singh MD, Sathya Sagar MD, Muniraju Maralakunte MD, Vikas Bhatia MD, Anindita Sinha MD, Gita Devi MD, M S Sandhu MD Department of Radio diagnosis, PGIMER Chandigarh, India * Corresponding Author: Uma Debi MD, Department of Radio diagnosis, PGIMER Chandigarh, India, E-mail: debi_uma@yahoo.co.in Received: 16 June 2020; Accepted: 17 July 2020; Published: 09 September 2020 Abstract Malignant bone lymphomas are a rare disease. According to an initial extent, bone lymphoma can be primary or secondary. Primary lymphoma of bone (PLB) has an overall good prognosis, commonly involves meta-diaphysis of long bones. Secondary osseous lymphoma preferentially involves an axial skeleton. Musculoskeletal lymphoma requires multimodality imaging evaluation by radiograph, CT, MRI, bone scintigraphy, and 18F-FDG PET-CT. Medullary bone lesion without cortical involvement is an important feature of lymphoma and it must be considered as a differential of a permeative bone lesion with soft tissue involvement. Muscular lymphoma does not have characteristic imaging findings. The final diagnosis of musculoskeletal lymphoma requires histopathology analysis. Keywords: Malignant bone lymphomas; Muscular lymphoma; Imaging 1. Introduction Musculoskeletal lymphoma is an infrequent but important differential of primary bone/ soft tissue tumor and must be considered as a differential of a permeative bone lesion with soft tissue involvement. In 1928, Oberling suggested that the reticuloendothelial cells of bone are primary tumor cells for primary reticulum cell sarcoma of bone. In 1939, Parker and Jackson presented 17 cases of primary reticulum cell sarcoma of bone and described their clinical, radiographic, and histopathological characteristic. They reported an overall good prognosis and survival rate in these cases. It was included as a separate type of bone tumor by Ewing in 1939 in the Registry of Bone Sarcoma of American College of Surgeons [1-4]. Studies from Mayo clinic demonstrated that though reticulum cells were