~ 14 ~ International Journal of Unani and Integrative Medicine 2020; 4(1): 14-17 E-ISSN: 2616-4558 P-ISSN: 2616-454X IJUIM 2020; 4(1): 14-17 Received: 10-11-2019 Accepted: 12-12-2019 Dr. Mohd Azfar PG Scholar, Dept. of Munafeul Aza, A & U Tibbiya College Karol Bagh Delhi, New Delhi, India Mohd. Saleem PG Scholar, Dept. of Munafeul Aza, A & U Tibbiya College Karol Bagh Delhi, New Delhi, India Yusuf Jamal Professor, Dept. of Munafeul Aza, A & U Tibbiya College Karol Bagh Delhi, New Delhi, India Corresponding Author: Dr. Mohd Azfar PG Scholar, Dept. of Munafeul Aza, A & U tibbiya College Karol Bagh Delhi, New Delhi, India Study of sleep, wake pattern in healthy individuals with reference to different Mizaj Dr. Mohd Azfar, Mohd. Saleem and Yusuf Jamal Abstract Sleep is reversible state of human that disengages the body from environment and makes body unresponsiveness. Sleep plays vital role for different physiological and psychological functions and makes body to recover and gain strength for further functions. It is considered an important part of life that leads to enhance many life functions such as memory processing and consolidation of various stimuli, development of brain cells and its complex cellular connections within the brain. Sleep is important for rapid cell division and immunity boosting event makes body smart to survive. Unani system of medicine is solely based on the fundamentals of Mizaj (temperament) and Tabiyat (physis). Homeostasis of Mizaj reflects healthy state of the body and any deviation of Mizaj either qualitative or quantitative leads to diseased condition. According to unani system of medicine there are six essential pre-requisites necessary for life called Asbaab-e-Sitta Zarooriya and Naum Wa Yaqza (sleep and wakefulness) is one of them. Mizaj of human beings is closely related to sleep and nature of sleep affects Mizaj of the humans and vice versa. Keywords: Tabiyat, Mizaj, Asbab-e-Sitta Zarooriya, Naum wa Yaqza, Ajnas-e-Ashrah Introduction Mizaj is basic fundamental principle of Unani medicine, produced when different Kaifiate Arba (qualities) of Arkan (elements) acts and reacts with each others, then previous qualities is replaced by moderate quality known as Mizaj [1] . Since Akhlat (Humours) has its own temperament as it is a mixture of four Khilt (Humour) i.e, Dam (Sanguis), Balgham (Phlegm), Safra (Yellow Bile) and Sauda (Black bile). These four humours combine intermix and form body fluid. Maintenance of mizaj-e-motadil means the maintenance of static or constant conditions (homeostasis) in the internal environment of the cells or the whole body [2] . Unani physician have devised some means and ways with certain parameters to diagnose the Mizaj called Ajnas-e-Ashra which are purely based on the sign and symptoms of the individuals. According to an easy definition sleep is reversible behavioural state of perceptual separation from and unresponsiveness to the surroundings. Sleep is a state of reduced awareness and responsiveness and is associated with reduced movement. Sleep plays an important role to anchor the immunity of an individual and the process of cell division becomes quite rapid during sleep. It is experienced that sleep may have some role in the development of brain cells and connection between them during development of the body. Sleep is involved in memory processing and consolidation gained during previous experience. It is the universal requirement of entire higher life forms including humans and absence of which has serious cause. Globally the world sleep day is celebrated on 13 March to raise awareness of sleep disorders and to reduce burden of sleep problem [3] . Sleep Architecture Normal human sleep is comprises of two states one is non rapid eye movement (NREM) sleep and other is rapid eye movement (REM) sleep these runs cyclically while sleeping. [3] NREM sleep is further classified into four stages 1, 2, 3, and 4, that represent relative depth of the sleep and each stage has a peculiar characteristic in brain wave patterns in EEG, eye movements, and muscle tone. I. NREM Sleep Sleep begins with NREM and forms about 75 to 80 % of total sleep. On the EEG during stage 1, the brain activity transitions from wakefulness to low voltage, mixed frequency waves called rhythmic alpha wave. Sleep during NREM stage 2 occurs about 10 to 25