International Journal of Health Sciences & Research (www.ijhsr.org) 468 Vol.7; Issue: 8; August 2017 International Journal of Health Sciences and Research www.ijhsr.org ISSN: 2249-9571 Review Article A Review on Ehlers-Danlos Syndrome V. Jagadeesh Naik 1 , B. Aswani 2 , P. Yanadaiah 3 , K. Hemachandra 4 , C. Madhusudhana Shetty 5 1 Pharm D V Year, 2,3 Assistant Professor, 4 Pharm D V Year, 5 Principal, Department of Pharmacy Practice, Santhiram College of Pharmacy, Nandyal, A.P. Pin -518501. Corresponding Author: V. Jagadeesh naik ABSTRACT Ehlers-Danlos syndrome (EDS) is a group of inherited disorders that affect the connective tissues primarily skin, joints, and blood vessel walls. Connective tissue is a complex mixture of proteins and other substances that provides strength and elasticity to the underlying structures in the body. People who have Ehlers-Danlos syndrome usually have overly flexible joints and stretchy, fragile skin. This can become a problem if a person has a wound that requires stitches, because the skin often is not strong enough to hold them. A more severe form of the disorder, called vascular Ehlers-Danlos syndrome, can cause the walls of the blood vessels, intestines or uterus to rupture. If a person has a vascular Ehlers-Danlos syndrome, he/she may want to talk to a genetic counselor before starting a family. EDS is typically classified into six types like The Classical type (formerly types I and II), The Hyper mobility type (type III), The Vascular type (type IV), The Kyphoscoliosis type (type VI), The Arthrochalasial type (type VIIA and VIIB), The Dermatosparaxis type (type VIIC). The combined frequency of EDS is 1 in 5000 individuals worldwide. Major mutations in COL5A1 gene and COL5A2 genes are responsible for EDS. There is more chance to autosomal inheritance of EDS. There is no specific therapy to cure Ehlers-Danlos syndrome. Physical therapy is often needed. Some of the other medications are under different phases of clinical trials. Key words: Ehlers – Danlos syndrome, connective tissues, mutations, autosomal inheritance. INTRODUCTION EHLERS-DANLOS SYNDROME (EDS) is a group of disorders that affect the connective tissues that support the skin, bones, blood vessels and many other organs and tissues. Defects in connective tissues cause the signs and symptoms of EDS, which vary from mildly loose joints to life threatening complications. [1] Classification Previously, there were more than 10 recognized types of EDS, differentiated by roman numerical. In 1997, researchers proposed a simpler classification that reduced the number of major types to six and gave them descriptive names  The classical type (formerly types I and II)  The hyper mobility type (type III)  The vascular type (type IV)  The kyphoscoliosis type (type VI)  The arthrochalasia type (type VIIA and VIIB)  The dermatosparaxis type (type VIIC) This six-type classification, known as the villefranche nomenclature, is still commonly used. The types are distinguished by their signs and symptoms, their underlying genetic causes, their patterns, of inheritance. [1] Sine 1997, several additional forms of the condition have been described. These additional forms appear to be rare,