International Journal of Health Sciences & Research (www.ijhsr.org) 269 Vol.7; Issue: 10; October 2017 International Journal of Health Sciences and Research www.ijhsr.org ISSN: 2249-9571 Case Report Ossifying Fibroma of Jaw: A Clinico-Radiographic Case Series Dr Satyapal Johaley 1 , Dr Freny R Karjodkar 2 , Dr Kaustubh P Sansare 3 , Dr Sneha R Sharma 1 , Dr Shikha Goyal 4 1 Postgraduate Student, 2 Prof and HOD, 3 Associate Professor, 4 MDS, Department of Oral Medicine and Radiology, Nair Hospital Dental College, Mumbai Central, Mumbai, Maharashtra, India Corresponding Author: Dr Satyapal Johaley ABSTRACT Ossifying fibroma (OF) is benign uncommon tumor usually unilocular occasionally multilocular fibro-osseous lesion, mainly involves craniofacial skeleton arising from the cells of the periodontal ligament, composed of fibrous connective tissue with a variable amount of mineralized materials. Mostly smaller in size diagnosed incidentally during routine dental radiographs, larger lesions the patient may complain of swelling with a displacement of teeth. OF shows varying radiographic patterns based on the amount of mineralized tissue and degree of maturation of the lesion. The timely diagnosis and management of the tumor are important to limit the spread and to reduce the morbidity of the patient. This article presents a series of cases of Ossifying fibroma along with the importance of advance imaging in diagnosis of ossifying fibroma. Keywords: Ossifying Fibroma, Giant cement-ossifying Fibroma, Fibro osseous lesion, CBCT. INTRODUCTION Ossifying Fibroma (OF) is uncommon benign fibro-osseous tumor commonly affecting the craniofacial region. The first description of ossifying fibroma was given by Menzel in 1872, calling it a cement ossifying fibroma. [1] Montgomery in 1927 first used the term OF 2 . In 1948 Sherman and Sternberg give the detailed description of the clinical, radiological and histological characteristics of OF. [3] Ossifying and/or cementifying fibroma arises from periodontal membrane a layer of fibrous connective tissue surrounding the roots of the teeth, which contains multipotential cells that are capable of forming cementum, lamellar bone, and fibrous tissueas a result of which they constitute histological variants of thesame pathological process. [4] The histopathology of the tumor may be confused with other fibro-osseous lesions, thus the final diagnosis requires correlation of the clinical histopathology and radiographic findings. [5,6] Advanced imaging modalities like CT and CBCT scans are very helpful in the investigation, especially in extensive cases since it defines the extent of the lesion and destruction of the surrounding structure. Case Report 1 A 36 years old female patient reported with chief complain of food lodgement in mandibular right first molar and swelling in right premolar region. The patient reported having suffered trauma in that same area 4 years ago had ahistory of extraction of the fractured mandibular second premolar. The patient had ahistory of hypothyroidism, endocrinology report