International Journal of Health Sciences & Research (www.ijhsr.org) 38 Vol.7; Issue: 11; November 2017 International Journal of Health Sciences and Research www.ijhsr.org ISSN: 2249-9571 Original Research Article Histomorphological Variation of Breast Lump in Lumbini Zone of Nepal Rajeeva Dhar Dwivedee 1 , Nabin Shrestha 2 , Anup Pandeya 3 1 Lecturer, Department of Pathology, Kathmandu University, Devdaha Medical College and Research Institute (DMCRI), Devdaha, Rupandehi, Nepal. 2 Lecturer, Department of General Surgery, Kathmandu University, Devdaha Medical College and Research Institute (DMCRI), Devdaha, Rupandehi, Nepal. 3 Lecturer, Department of Anatomy, Kathmandu University, Devdaha Medical College and Research Institute (DMCRI), Devdaha, Rupandehi, Nepal. Corresponding Author: Rajeeva Dhar Dwivedee E-mail: rajeevdwivedee@gmail.com ABSTRACT Background: Breast lump can present as inflammatory to neoplastic lesion. Any kind of lesion present in breast makes anxiety to patient for cancer. Histopathology is key for confirm each lesion. Objective: This study is aimed to observe histomorphological variation of excised breast lump in Lumbini zone of Nepal. Materials & methods: Prospective descriptive study was done from April 2016 to October 2016 of excised 54 cases of all female breast lumps in National Path Lab, Rupendehi, Nepal. FNAC and excised male breast lump were excluded from the study. Results: The entire excised breast lumps were categorized as Inflammatory, Non-neoplastic and Neoplastic. Neoplastic is classified as Benign and Malignant lesion. Out of 54 cases aged from 15 -72 years, Fibroadenoma, Fibrocystic Disease, Abscess/Mastitis and Invasive Ductal Carcinoma was dominant lesion of each categories. Fibroadenoma, Fibrocystic Disease with equal frequency of 25.92%, Abscess/Mastitis and Invasive Ductal Carcinoma was22.22% and 7.40% respectively Conclusion: Malignant lesion was least common of each category with predominance of Invasive Ductal Carcinoma 7.40% .Invasive Ductal Carcinoma was prevalent in 7 th decades. Key words: Breast Lump, Fibroadenoma, Histopathology INTRODUCTION Breast is organ which can change according to marital status and age of patient. (1) Due to awareness of patient, for any palpable breast swelling, pain and discharge from breast make anxious to patient for malignant lesion. (2) Most common cancer of female in western world is breast cancer and is most common cause of death in 4 th to 6 th decades. (1) Lesions in breast varied according to age group and carcinoma of breast is extremely rare before 2 nd decades and is rises after this age and almost 20% upto 9 th decade. (1) Incidence of breast cancer in Asian patient are more commonly seen in younger age group compare to western and nearly one fourth breast cancer in young age. (3) Benign breast lesion are most common lesion of all breast lesion of earlier age group, among them most common were Fibroadenoma and Fibrocystic disease. Despite knowing this excision biopsy is performed to rule out malignant lesion. (4) Most of lesions are diagnose on the basis of clinical history, physical