RESEARCH ARTICLE Open Access
Patient and disease characteristics
associated with late tumour stage at
presentation of cervical cancer in
northwestern Tanzania
Ramadhani Mlange
1
, Dismas Matovelo
1*
, Peter Rambau
2
and Benson Kidenya
3
Abstract
Background: About two thirds of patients with cervical cancer in Tanzania present with advanced tumor stage,
leading to significant morbidity and mortality. We designed a study to determine the factors associated with the
late tumour stage at presentation among patients with cervical cancer in Mwanza.
Methods: This cross-sectional study recruited women at Bugando Medical Centre (BMC) with histologically
confirmed cervical cancer from November 2013 to April 2014. Patients were recruited serially until the sample size
was reached.
Results: A total of 202 women with histologically confirmed cervical cancer were recruited. The mean age of the
patients was 50.5 ± 13.3 years. The majority of patients (n = 129, 63.9 %) were diagnosed with late stage disease
(IIB-IVB). Patients also presented with severe anemia (n = 78, 38.6 %), urinary tract infections (n = 74, 36.6 %),
hydronephrosis (n = 43, 21.2 %), elevated serum creatinine levels (n = 33, 16.3 %), vesicovaginal fistula (VVF), (n = 13,
6.4 %), lung metastasis (n = 5, 2.4 %), metastasis to the urinary bladder (n = 4, 1.9 %), rectovaginal fistula (RVF) (n = 3,
1.4 %), liver metastasis (n = 2, 0.9 %) and hydroureter (n = 2, 0.9 %). In multivariate logistic regression, factors
associated with late stage at presentation were attending to alternative health practitioners and lack of personal
initiative to seek care to formal health facilities (OR 2.3; 95 % CI 1.2–4.2, p = 0.011 and OR 2.0; 95 % CI 1.0–3.8,
p = 0.028) respectively.
Conclusion: Communities should be sensitized to women’s empowerment, provide community education on early
symptoms of cervical cancer, and the importance of early hospital attendance.
Keywords: Cervical cancer, Late presentation, Advanced stage, Mwanza
Background
Cervical cancer is the fourth common cancer among
women worldwide with nearly 529,000 incident cases
and 275,000 deaths each year [1]. More than 85 % of
these cases occur in developing countries due lack of
implementation campaigns aimed at cancer prevention,
such as screening for early detection and vaccination for
Human Papillomavirus (HPV) infection [1]. The highest
burden of cervical cancer-related deaths occur in
developing countries and it is the leading cause of
gynecological cancer-related deaths among women in
Sub-Saharan Africa, Central America and South-Central
Asia [2]. In Tanzania, approximately 3,000 new cervical
cancer patients are seen at Ocean Road Cancer Institute
per year and 47 % of these patients present with ad-
vanced stage disease [3]. At Bugando Medical Centre
(BMC), 400 patients with cervical cancer are seen per
annum [4].
Patients who present with advanced stage disease are
more likely to develop complications such as anemia,
ureteric obstruction with hydroureter and hydronephrosis,
renal failure and urinary tract infection [5, 6]. Cervical
* Correspondence: magonza77@yahoo.co.uk
1
Department of Obstetrics & Gynecology, Catholic University of Health &
Allied Sciences, P.O. BOX 1464, Mwanza, Tanzania
Full list of author information is available at the end of the article
© 2016 Mlange et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and
reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to
the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver
(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Mlange et al. BMC Women's Health (2016) 16:5
DOI 10.1186/s12905-016-0285-7