_____________________________________________________________________________________________________ *Corresponding author: Email: steve.manortey@ensign.edu.gh; International Journal of TROPICAL DISEASE & Health 41(15): 18-32, 2020; Article no.IJTDH.61600 ISSN: 2278–1005, NLM ID: 101632866 Impact of Mass Drug Administration on Prevalence of Schistosomiasis in Eight Riverine Communities in the Asuogyaman District of the Eastern Region, Ghana Quartey Abass 1 , John Yao Bedzo 1 and Stephen Manortey 1* 1 Ensign College of Public Health, Kpong, Eastern Region, Ghana. Authors’ contributions This work was carried out in collaboration among all authors. Authors QA, JYB and SM participated in conceiving the study and in the development of data collection tools. Author QA carried out data collection. Authors QA, JYB and SM participated in the data analysis and drafting of the manuscript. All authors read and approved the final manuscript. Article Information DOI: 10.9734/IJTDH/2020/v41i1530355 Editor(s): (1) Dr. Giuseppe Murdaca, University of Genoa, Italy. Reviewers: (1) Rashika El Ridi, Cairo University, Egypt. (2) Obiora O. Ikpeze, Nnamdi Azikiwe University, Nigeria. (3) Gihan Mostafa Tawfeek Saber, Ain Shams University, Egypt. Complete Peer review History: http://www.sdiarticle4.com/review-history/61600 Received 20 July 2020 Accepted 27 September 2020 Published 14 October 2020 ABSTRACT Background: The incidence of schistosomiasis in Ghana and more specifically in the Asuogyaman District had become a noticeable record following the creation of the Akosombo Dam in the early 1960s. This has inevitably since placed an enormous burden on the health service delivery systems in the geographical area. Mass Drug Administration (MDA) of Praziquantel has been used worldwide as a preventive and treatment intervention measure for the disease, and the study area is no exception. The study, therefore, aimed to assess the impact of MDA on the prevalence and associated risk factors of schistosomiasis in eight (8) selected riverine communities within the district. Methods: A descriptive retrospective cross-sectional study was conducted involving 896 respondents with ages ranging from 2 to 82 years and a mean age of 17±13.78 years. Data were obtained from the Volta River Authority (VRA) Public Health and Environmental Department. Original Research Article