J Bioinform Syst Biol 2020; 3 (4): 081-091 DOI: 10.26502/jbsb.5107016 Journal of Bioinformatics and Systems Biology Vol. 3 No. 4 – December 2020 81 Research Article Emergence of a Pathogenic Strain of COVID-19 Shreyans Chatterjee 1,4 , Tathagata Dey 2,4* , Smarajit Manna 3,4 1 Microbiology Department, St. Xavier’s College, Kolkata, India 2 Computer Science Department, Government College of Engineering and Textile Technology, West Bengal, India 3 Jagadis Bose National Science Talent Search, Kolkata, India 4 Centre for Interdisciplinary Research and Education, Kolkata, India * Corresponding Authors: Tathagata Dey, SBGP757, Santinagar, P.O. Sapuipara, P.S. Nischinda, Bally, Howrah, West Bengal, India, Tel: +91 8296471895; E-mail: tathagata2403@gmail.com Received: 27 August 2020; Accepted: 28 September 2020; Published: 15 October 2020 Citation: Shreyans Chatterjee, Tathagata Dey, Smarajit Manna. Emergence of a Pathogenic Strain of COVID-19. Journal of Bioinformatics and Systems Biology 3 (2020): 081-091. Abstract SARS-CoV-2 pandemic starting from Wuhan, China has now been spreading worldwide making the infection count more than 41 million. Within a short time span, many mutations are continuously occurring in the viral genome, be it point mutation or frameshift mutation. Scientists have been suggesting that, one of those numerous point mutations is becoming prevalent by replacing all the initial Wuhan strains of SARS-CoV-2. In this work, we have conducted a rigorous bio-informatic analyses and compared the properties of wild and mutant strains to find out the changes. Eventually, it is considered to be a more pathogenic and infective strain by our theoretical reports with a change in amino acid position number 614, which coincidentally converges with one or few publications mentioning emergence of new pathogenic D614G strain. Here we describe our approach to arrive at the conclusion. Keywords: Mutation; SARS-CoV-2; D614G; Pathogenicity;   ; Polar plot; Protein 1. Introduction SARS-CoV-2 or COVID-19 being a pandemic (declared by W.H.O. on 11 th March, 2020) has already spread to 211 countries worldwide, making the total count of infection cases to 7,273,958 with 413,372 deaths as on 11 th June, 2020 [1]. SARS-CoV-2, commonly called as COVID-19, is an enveloped, single-stranded positive sense RNA virus,