719 WFN15-1458 Miscellaneous Topics 3 Validation and diagnostic utility of the everyday Cognition (ECOG) in Argentina-ADNI M. Russo, P. Chrem Mendez, J. Campos, G. Cohen, A. Amengual, F.E. Nahas, M.E. Martín, M.F. Clarens, F. Tapajoz, P. Harris, G. Sevlever, R.F. Allegri. Cognitive Neurology, Raúl Carrea Institute for Neurological Research (FLENI), CABA, Argentina Introduction: The detection and characterization of functional impairments in patients with cognitive impairment is an important clinical and research issue. The Everyday Cognition (ECog) scale is a relatively new informant-rated measure of everyday function. Objective: The objective of this study was to determine the indices of validity and internal consistency of the ECog in the Argentina- Alzheimer´s Disease Neuroimaging Initiative (Arg-ADNI) sample. Methods: We assessed 15 clinically normal elderly (CN), 28 mild cognitive impairment (MCI), and 13 mild Alzheimer´s Disease (AD) dementia subjects from Arg-ADNI. External, convergent and diver- gent validity and internal consistency were examined. Results: The average total score on the ECog scale was significantly different across the three diagnostic syndromes (p b 0.5). The area under the curve (AUC) for the ECog was .97 (95% CI = .93-.99). The ECog scale was more sensitive than FAQ in discriminating between those with any cognitive impairment (either dementia or MCI) and CN. The ECog scale showed a moderate to strong correlation with other measures of daily function, including the Clinical Dementia Rating (CDR) and the FAQ scales and moderate correlations with neuropsychological tests. Cronbach´s alpha was .98. Co-varying for age or education had no effect on these results. Conclusions: The ECog scale is an efficient instrument for the differentiation of individuals with mild dementia or MCI from normal older adults, with good accuracy and good correlation with other tests measuring daily and cognitive functions. doi:10.1016/j.jns.2015.08.789 720 WFN15-1461 Miscellaneous Topics 3 The association between neuropsychological functioning and driving performance in older people with mild dementia L. Crivelli, M. Russo, M. Bonetto, C. Prado, M. Farez, L. Sabe, R.F. Allegri. Cognitive Neurology, Raúl Carrea Institute for Neurological Research (FLENI), CABA, Argentina Introduction: As life expectancy, there is a growth in proportion of elderly people who want to continue driving. On the other hand, age is a risk factor for the development of dementia. While it has been established that patients with mild dementia are higher-risk drivers, it is also true that a large proportion of them can drive safely. Objective: To measure the association of cognition and driving safety in healthy older drivers and in patients with mild dementia. Methods: A group of 28 patients with mild dementia by Clinical Dementia Rating (CDR b 1) was evaluated with a group of 28 age and education-matched controls. All participants underwent a cognitive assessment and a driving assessment battery (driving simulator and on-road test). Results: Drivers with dementia made more mistakes in the on-road test and had slower responses in the subtests of brake reaction and signal recognition of the simulator. TMT B, semantic fluency and AD8 interview were the cognitive measures that best predicted driving performance. Other set of tests that correlated with the on-road test, but only with brake reaction or traffic signal detection subtests of the simulator were MMSE, Logical Memory, TMT A, Digit Symbol Test, Boston Naming Test, Verbal and Visual Learning test (Rey), Frontal Assessment Battery, Neuropsychiatric Inventory and the functional assessment questionnaire. Conclusion: The strong correlation between driving performance and specific cognitive tests supports the importance of cognitive assessment as a useful tool for deciding whether patients with dementia can safely operate a motor vehicle. doi:10.1016/j.jns.2015.08.790 721 WFN15-1463 Miscellaneous Topics 3 Diagnostic accuracy of the phototest for cognitive impairment and dementia in Chile N. Lopez a , M. Russo b , A. Véliz a , D. Martella c , C. Carnero Pardo d , R.F. Allegri b . a Department of Social Sciences, Universidad de los Lagos, Puerto Montt, Chile; b Cognitive Neurology, Raúl Carrea Institute for Neurological Research (FLENI), CABA, Argentina; c School of Psychology, University of Chile, Puerto Montt, Chile; d Cognitive Neurology, Hospital Universitario Virgen de las Nieves, Granada, Spain Introduction: Phototest is a simple, easy and very brief test with theoretical advantages over available dementia screening tests in Spain and Argentina. Objective: The objective of this study was to estimate the diagnostic accuracy of the Phototest for cognitive impairment and dementia and to compare it with that of the MMSE in a Chilean population. Methods: A phase I cross-sectional study of diagnostic tests evaluation was performed in a sample of 58 controls, 11 with amnestic mild cognitive impairment (a-MCI), and 29 with mild Alzheimer type dementia (DAT). The diagnostic accuracy (DA) was assessed in relation to the clinical diagnosis by calculating the area under the ROC curve (UAC), Sensitivity (Sn), and Specificity (Sp). Results: The DA of the Phototest for a-MCI and DAT (0.90 and 0.99 [UAC]) was higher than that of the MMSE. The cut-off points of 25/26 for DAT (Sn = 98.3, Sp = 89.7) and 26/27 for a-MCI (Sn = 96.6, Sp = 81.8) maximized the sum of Sn and Sp. Phototest correlates significantly with MMSE (r = .801). Phototest results were not influenced by the level of schooling or literacy. Conclusions: The Phototest is an efficient instrument for the detection of mild dementia or MCI, with good accuracy and good correlation with tests measuring overall cognitive impairment and its results are not influenced by sociodemographic variables. doi:10.1016/j.jns.2015.08.791 722 WFN15-0375 Miscellaneous Topics 3 Sensory processing abnormalities in children with severe autism – Do they correlate with FDG-PET findings? P. Singhi a , R. Adam Kadwa a , J.K. Sahu a , P. Malhi a , B.R. Mittal b . a Pediatrics, Post Graduate Institute of Medical Education and Research, Chandigarh, India; b Nuclear Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India Background: Systemic studies of Sensory Processing Abnormalities (SPAs) and FDG-PET in children with autism are lacking. Objective: To study SPAs in children with severe autism and their correlation with FDG-PET findings. Abstracts / Journal of the Neurological Sciences 357 (2015) e215–e234 e230