1 Original Article Running Title: Prostate Cancer and Affected Factors Received: July 13, 2019; Accepted: July 22, 2020 An Investigation of the Pathology Report of Prostate Cancer Patients with Radical Prostatectomy in Southern Iran, during 2013 and 2018: A Cross-sectional Study Ali Ariafar *,** , Shahryar Zeighami *,** , Mehdi Salehipour *,** , Faisal Ahmed *,***♦ , Zahra Shahabi * , Hossein-Ali Nikbakht **** *Department of Urology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran ** Urology Oncology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran *** Department of Urology, School of Medicine, Ibb University of Medical Sciences, Ibb, Yemen **** Social Determinates of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran ♦ Corresponding Author Faisal Ahmed, MD Dar Alshefa Hospital, Taiz Street, Ibb, Yemen Tel: +967776089579 Email: fmaaa2006@yahoo.com Abstract Background: Prostate cancer is a major malignancy worldwide among men; it is the fourth leading cancer in both genders. This study investigated the pathologic factors of radical prostatectomy (RP) specimens. Method: About 578 men underwent RP during five years in Shiraz University hospitals. We recorded the following clincopathological parameters: tumor type and stage, Gleason score (GS), grade, tertiary pattern, ISUP, surgical margin, LN involvement, lymphovascular invasion, seminal vesicle involvement, extraprostatic extension (EPE), vas deferens invasion, perineural and pseudocapsular invasion, bladder neck involvement, and age. Result: The mean age of participants was 63.87 ± 6.95 years. Most had pathologic T2N0Mx (73 %) diseases; the most GS was low risk GS ≤ 6 (47.4%). Surgical margin status was free of tumors in 72.5% and among those with positive margins; the most involved site was the apex in 18.3%. Single and dual LN involvements were the most prevalent patterns. 5.9% of the patients had EPE. We found perineural and pseudocapsular invasions in 59.9% and 29.9%, respectively. There was a strong correlation between the clincopathological parameters, stage, and ISUP. Perineural invasion, pseudocapsular invasion, and tertiary pattern 5 increased with advanced age (P < 0.0001). The GS 8 to 10 increased with the increase in age (P =0.001). Conclusion: A strong correlation existed between the clincopathological parameters, stage, and ISUP. Additionally, perineural and pseudocapsular involvement and tertiary pattern 5 had a strong relationship with advanced age. Keywords: Prostate cancer, Radical prostatectomy, Pathology