www.iajpr.com Page1910 Indo American Journal of Pharmaceutical Research, 2014 ISSN NO: 2231-6876 Journal home page: http://www.iajpr.com/index.php/en/ INDO AMERICAN JOURNAL OF PHARMACEUTICAL RESEARCH SAFETY OF GLICLAZIDE WITH THE AQUEOUS EXTRACT OF TINOSPORA CORDIFOLIA ON PHARMACODYNAMIC ACTIVITY IN NORMAL AND ALLOXAN INDUCED DIABETIC RATS 1 M. Ganga Raju, 2 S. Satyanarayana, 2 Eswar Kumar 1 Department of Pharmacology, Gokaraju Rangaraju College of Pharmacy, Bachupally, Hyderabad, Andhra Pradesh, India. 2 Department of Pharmaceutical Sciences, Andhra University, Vishakapatnam, Andhra Pradesh, India. Corresponding author Dr. M. Ganga Raju Assosciate Professor and Head Department of Pharmacology, Gokaraju Rangaraju College of Pharmacy, Bachupally, Hyderabad, Andhra Pradesh, India mgrpharma@gmail.com Copy right © 2014 This is an Open Access article distributed under the terms of the Indo American journal of Pharmaceutical Research, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ARTICLE INFO ABSTRACT Article history Received 13/03/2014 Available online 30/04/2014 Keywords Tinospora Cordifolia, Hypoglycaemic, Antihyper Glycemic, Gliclazide. Herbal plants are used as medicines in folk and traditional medicinal practice based on the plants and plant extracts. The present study was carried out to evaluate the hypoglycemic activity and antihyper glycemic activity of aqueous extracts of whole plant of Tinospora cordifolia in normal and in alloxan induced diabetic rats. The aqueous extract of Tinospora cordifolia (30mg/Kg, 100mg/Kg, 200mg/kg, 300mg/Kg bd.wt) and the dose(200mg/Kg) that produced an optimal reduction (30-40%)of blood glucose was selected for the study. Blood samples were collected at desired intervals of time and analyzed for blood glucose by GOD- POD method. Gliclazide a second generation sulfonyl urea was selected for the interaction study with that of the Tinospora cordifolia. The doses of gliclazide (1mg/Kg, 2mg/Kg and 4mg/Kg bd.wt) were given to normal and diabetic rats and the dose (2mg/Kg bd.wt) that produced an optimal reduction of blood glucose was selected for the study. The aqueous extract of Tinospora cordifolia has shown reduction in blood glucose level in both normal and diabetic rats which were compared with the standard drug gliclazide. To find the interaction of aqueous extract of Tinospora cordifolia with the standard drug gliclazide, the extract was given prior to the gliclazide administration. The results have shown that the prior administration of Tinospora cordifolia significantly increased the hypoglycemic and antihyperglycemic activity of gliclazide. Please cite this article in press as Dr. M. Ganga Raju et al. Safety of Gliclazide with the Aqueous Extract of Tinospora Cordifolia on Pharmacodynamic Activity in Normal and Alloxan Induced Diabetic Rats. Indo American Journal of Pharm Research.2014:4(04).