Shubhangi Parbhane et al, Int. Journal of Pharmaceutical Sciences and Medicine (IJPSM), Vol.5 Issue. 12, December- 2020, pg. 11-22 ISSN: 2519-9889 Impact Factor: 3.426 © 2020, IJPSM All Rights Reserved, www.ijpsm.com 11 SOLUBILITY ENHANCEMENT: MEANING AND TECHNIQUES Shubhangi Parbhane; Aarti Belure; Aniket Garud; Mrs. Vibhavari Chatur* Rasiklal M. Dhariwal Institute of Pharmaceutical Education and Research, Chinchwad, Pune-19 E.mail Id: shubhangiparbhane22@gmail.com, aartibelure@gmail.com, ani.pharmacology@gmail.com, vibhavaric@gmail.com DOI: 10.47760/ijpsm.2020.v05i12.005 Abstract: The solubility enhancement process of hydrophobic drugs is crucial in formulation development to achieve the bioavailability and therapeutic action of the drug at the target site. About 40% of the new chemical entities that have been identified by pharmaceutical industry screening programs face numerous problems in the formulation and development stage due to the poor water solubility and low bioavailability. Drug solubility and bioavailability enhancement are the important challenges in the field of formulation of pharmaceuticals. The Bio pharmaceutics Classification System depicts that Class II and IV drugs have a low water solubility, poor dissolution, and low bioavailability. This review highlights on the importance, advantages, disadvantages, techniques of solubility enhancement. Keywords: Solubility, BCS Classification, Solubility Enhancement Techniques, Solubility Enhancers. Introduction: Solubility, the phenomenon of dissolution of solute in solvent to give a homogenous system, is the main parameter to achieve desired concentration of drug in systemic circulation for desired pharmacological response. Low hydrophilicity is the major problem encountered with formulation development of new chemical entities and also for the generic development. The insufficient dissolution rate of the drug is the limiting factor in the oral bioavailability of poorly water soluble compounds. This review discusses BCS classification, carriers for solubility enhancement and different techniques for solubility enhancement. Different techniques are used to enhance the solubility of poorly soluble drugs which consist of micronization, nanonization, sonocrystallization, supercritical fluid method, spray freezing into liquid and lyophilisation, evaporative precipitation into aqueous solution, use of surfactant, use of co-solvent, hydrotropymethod, use of salt forms, solvent deposition, agents, modification of the crystal habit, co-crystallisation, complexation and drug dispersion in