International Journal of Public Health Science (IJPHS) Vol. 9, No. 4, December 2020, pp. 333~337 ISSN: 2252-8806, DOI: 10.11591/ijphs.v9i4.20408  333 Journal homepage: http://ijphs.iaescore.com Hormonal profile and characteristics of polychistic ovarium syndrome among Madurese tribe, Indonesia Zakkiyatus Zainiyah, Eny Susanti, Mustofa Haris Ngudia Husada Madura College of Health Sciences (STIKes), Indonesia Article Info ABSTRACT Article history: Received Jan 23, 2020 Revised Aug 10, 2020 Accepted Sep 5, 2020 Polycystic ovarium syndrome (PCOS), the most common endocrine disorders in women of reproductive age, characterized by menstrual disorders (amenorrhea/oligomenorrhea), hirsutism, the appearance of acne, alopecia and the results of biochemical tests that show increased androgens (testosterone). Increased serum luteinizing hormone (LH) and follicle stimulating hormone (FSH) serve as diagnostic tests for PCOS over the years, but from several research results obtained inconsistent results that need further research. The purpose of this study is to analyze the hormonal profile and characteristics of polycystic ovary syndrome (PCOS) in Madura. Case-control study conducted in March-August 2019 in the Madura tribe. There were 32 subjects with PCOS and 32 healthy women participated in this study. Hormonal examination was using a serum and followed by enzyme- linked immune sorbent assay (ELISA kit). Levels Follicle-stimulating hormone (FSH) average was 8.74 and SHBGs were 10.02 lower in PCOS patients and LH levels were higher in PCOS patients; ratio LH/FSH was 0.76. The results of the Madurese study showed that levels of FSH, LH, weight significantly related to PCOS sex hormone binding globulin (SHBG), however body mass index (BMI) levels were not related to PCOS. Keywords: Body mass index (BMI) Follicle-stimulating hormone Luteinizing hormone (LH) Polycystic ovarium syndrome Weight This is an open access article under the CC BY-SA license. Corresponding Author: Zakkiyatus Zainiyah, Department of Professional Midwifery, Ngudia Husada Madura Institute of Health Sciences (STIKes), Jl. RE. Martadinata No 45, Mlajah Bangkalan, Indonesia. Email: zzainiyah@gmail.com 1. INTRODUCTION Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women of reproductive age, characterized by menstrual disorders (amenorrhea/oligomenorrhea), hirsutism, emergence of polycystic ovary syndrome (PCOS), one of the most common endocrine disorders in women of reproductive age, characterized by menstrual disorders (amenorrhea/oligomenorrhea), hirsutism, emergence of polycystic ovary syndrome (PCOS) the results of biochemical examination showed that androgens (testosterone) were increased [1-3]. Long-term effects of PCOS usually occur with infertility, insulin resistance, increased risk of diabetes and cardiovascular disease [4, 5]. El Hayek said the prevalence of PCOS is around 4% to 10% of women worldwide [1]. There are three criteria for the diagnosis of PCOS, namely the national institutes of health (NIH) Criteria, the criteria for androgen excess and polycystic ovarian syndrome society (AE-PCOS), and Rotterdam criteria. The Rotterdam Criteria is a consensus that resulted from a conference organized by the European society for human reproduction and embryology/the American society for reproductive medicine (ESHRE/ASRM) in 2003. A diagnosis of PCOS is established by the Rotterdam criteria if two of the following