IJSRST20723 | Accepted : 01 March 2020 | Published : 04 March 2020 | March-April-2020 [ 7 (2) : 68-74 ] © 2020 | International Journal of Scientific Research in Science and Technology IJSRST | Volume 7 | Issue 2 | Print ISSN: 2395-6011 | Online ISSN: 2395-602X DOI : https://doi.org/10.32628/IJSRST20723 68 Design, Synthesis and Characterization of Some Novel benzamide derivatives and it’s Pharmacological Screening Akshay R. Yadav*, Shrinivas K. Mohite Department of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon, Maharashtra, India Corresponding author E-mail:- akshayyadav24197@gmail.com ABSTRACT The new series of substituted N-(phenylcarbamothioyl)benzamide derivatives (2a-2f) was designed, development and synthesized by using conventional and microwave method. In present work six different N-(phenylcarbamothioyl)benzamide were synthesized. Substituted benzoyl chloride is converted into benzoyl isothiocyanate by esterification. Benzoyl isothiocyanate is converted into Substituted (phenylcarbamothioyl)benzamide by treating with substituted aniline. Confirmation of the chemical structure of the synthesized was substantiated by TLC, IR, 1H NMR, MS spectroscopy. Novel synthesized compounds screened for their in vivo and in-vitro anti-inflammatory studies and compound 2f shows promising anti-inflammatory activity. Keywords: Benzamide, Microwave, Anti-Inflammatory Activity I. INTRODUCTION Benzamide used in medicinal as well as non- medicinal activities in industry. Thiourea is organic compound having sulphur with the general formula (R1R2N)(R3R4N)C=S. Thiourea and urea derivatives show a broad spectrum of biological activities as anti- HIV, antiviral, HDL-elevating, antibacterial and analgesic properties. Acyl thiourea derivatives are well known for wide range of biological activities like bactericidal, fungicidal, herbicidal, insecticidal action and regulating activity for plant growth. Thiourea derivatives are exceptionally versatile building blocks for the synthesis of a variety of heterocyclic compounds. Diaryl thioureas exhibit significant antifungal activity against the plant pathogens. Acyl thioureas are well known for their superior pesticidal, fungicidal, antiviral, and regulating activity for plant growth. Thiourea derivatives have attracted great attention as versatile ligands in numerous applications. Benzamide is an aromatic amide that consists of benzene bearing a single carboxamido substituent. Over 30 drugs containing this functionality are in clinical use, including antihypertensive agent, antibacterial, antiprotozoal, antifungal, anti- inflammatory, nonpeptidic vasopressin receptor antagonists and translation initiation inhibitors. Some important benzamide derivatives used as carbonic anhydrase inhibitors of commercial importance. “Green chemistry” is defined as the synthesis, design, development and application of chemical products to reduces hazardous substances. The application of green chemistry principles and practices renders regulation, control, clean-up, and remediation of the environment. Thus its benefits can be expressed in terms of economic impact. Therapeutically active and new drug constituents are needed for the treatment of different diseases.