International e-Conference on "Sustainable Development : A Biological and Socioeconomical Perspective |61 Int. Res. J. of Science & Engineering, Special Issue A8, July, 2020 SJIF Impact Factor 6.70 ISSN: 2322-0015 RESEARCH ARTICLE OPEN ACCESS A Alteration of Free Amino Acid in Mice Exposed to Toxicant Pawar Santosh S, Patil KG, Deshmukh PS, Surwase SS, Kale MD and Nagale VK* Govt. Vidarbha Institute of Science and Humanities, Amravati- 444604(MS) India *Sant Gadge Baba Amravati University, Amravati *Corresponding author: E. Mail-sspawar2727@gmail.com Manuscript Details Abstract Available online on https://www.irjse.in ISSN: 2322-0015 Editor: Dr. Arvind Chavhan Cite this article as: Pawar Santosh S, Patil KG, Deshmukh PS, Surwase SS, Kale MD and Nagale VK. A Alteration of Free Amino Acid in Mice Exposed to Toxicant , Int. Res. Journal of Science & Engineering, 2020, Special Issue A8:61-64. Article published in Special issue of International e- Conference on "Sustainable Development : A Biological and Socioeconomical Perspective” organized by Government Vidarbha Institute of Science and Humanities Amravati, Maharashtra, India date, July, 26-27, 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/ Amino acid and nitrogen metabolism are of the utmost importance in animals, since amino acids are essential intermediates in protein synthesis. In the present study, we found that the free amino acid content alters during dieldrin exposure for 90 days at four different concentrations. At 14 days exposure period free amino acid contents were observed less, which later on showed an ascending trend up to the end of the experiment. In the lowest concentration of same toxicant from 0.1mg/kg to 0.5mg/kg body weight of mice for 14 days produced non-significant result but same toxicant at highest concentrations dose (2mg/kg body weight of mice) produced a significant impact on the liver FAA of mice as compared to control. It was proved that the impact of dieldrin on mice was duration dependant. Keywords: - Mice, liver, free amino acid, toxicant. Introduction After a food containing protein, the concentration of free amino a cid in the blood is greatly increased and therefore the liver is subj ected to repeated gross fluctuations in the supply of amino acids throughout the body. Liver is the animal's metabolic core and its disruption causes physiological and metabolic disturbance within the animal, any disruption in this system will definitely change the animal's physiological and metabolic disturbances. Protein metabolic functions in such a way that, can be used as alternative source of energy specially under the condition of stress [1-3].