IOSR Journal Of Pharmacy And Biological Sciences (IOSR-JPBS) e-ISSN:2278-3008, p-ISSN:2319-7676. Volume 16, Issue 1 Ser. II (Jan. – Feb. 2021), PP 29-36 www.Iosrjournals.Org DOI: 10.9790/3008-1601022936 www.iosrjournals.org 29 | Page Comparative Effect of Virgin Coconut Oil (VCO) and Coconut Milk On Fertility Profile (Male Sex Hormonal Analysis) Using Rats as Models. 1 Ebisintei P, 2 Nwankwo A A, 3 Alexis O 4 .Azunna U 1 Department of Biological Sciences, Faculty of Basic and Applied Sciences, University of Africa Toru Orua,Bayelsa State 2 Department of Physiology, College of Health Sciences, Abia State University, Uturu. 3 Department of Biological Sciences, Faculty of Basic and Applied Sciences, University of Africa Toru Orua, Bayelsa State. 4 Department of Physiology, College of Health Sciences, Abia State University, Uturu Summary. The comparative effects of Virgin Coconut oil (CocosNucifera) and Coconut milk on male sex hormone using male rats as model was studied. A total of 72 rats (40 adults male and 32 female) weighing between 200-250g were used in the study. Group 1 served as the control and received distilled water only. Groups 2-4 were the test groups and were fed with the coconut extracts orally. Group 2 was fed with virgin coconut oil (VCO), group 3 was feed with coconut milk (CM) while group 4 was fed with the mixture of coconut oil and coconut milk.( VCO+ CM) respectively. At the end of administration, assay of the reproductive hormones (FSH, LH, Testosterone) were carried out. The results of the study showed that the administration of Virgin Coconut milk (CM) and the mixture of Virgin Coconut oil (VCO) and Virgin Coconut milk (CM) resulted in no significant changes in FSH concentration when compared with the control. The virgin coconut oil (VCO) showed a highly significant decrease in FSH concentration (P<0.05) when compared with the control and also with coconut milk. Virgin Coconut milk (CM) administration showed a significant increase whereas Virgin Coconut oil (VCO) a significant decrease in LH concentration when compared with the control respectively. Also the administration of the coconuts extracts all have a decreased effects on the testosterone concentrations, significantly (P<.05) decreased by the Virgin Coconut oil (VCO). Administration of Virgin Coconut oil either directly or via our diets should be with caution because of possible impairment in the level of sex hormones, thereby affecting fertility. Keywords: Virgin coconut oil, coconut milk, testosterone, FSH, LH. --------------------------------------------------------------------------------------------------------------------------------------- Date of Submission: 23-01-2021 Date of Acceptance: 07-02-2021 --------------------------------------------------------------------------------------------------------------------------------------- I. Introduction Sex hormones such as testosterone, Luteinizing hormone and Follicle stimulating hormone play various physiological roles in the development of male reproductive system during puberty which enhances fertility (David JH et al., 2018). Regulation of Testosterone secretion Testosterone is produced in the Leydig cell in the testes (Aumuller G,and Seitz J 1990), the number of Leydig cells in turn is regulated by the luteinizing hormone (LH) and follicle stimulating hormone (FSH) (Paynr AH and O’ Shaughnessy P 1996). LH stimulates gene in the sertoli cells which in turn promote differentiation of