CH16113 | Received: 06 Dec 2016 | Accepted: 17 Dec 2016 | November-December 2016 [(1) 2: 01-06] International Journal of Scientific Research in Chemistry (IJSRCH) | ISSN : 2456-8457 © 2016 IJSRCH | Volume 1 | Issue 2 01 Synthesis and Characterizations of Oxazolo Pyrimidine Derivatives as Biological Active and Antiinfective Agents Department of Chemistry, M G Science Institute, Navarangpura, Ahmedabad, Gujarat, India ABSTRACT Pyrimidines are those molecules that make our life possible being the building blocks of DNA and RNA. Pyrimidine plays a significant role among other heterocycles. Literature survey reveals that partially reduced pyridine and Pyrimidine derivatives are known to have antihypertensive property. Pyrimidine nucleus was synthesized by Biginelli reaction. The aim of this study was to synthesize and introduse many title compound (1a -1m) evaluate them for their antibacterial and antifungal activity. The structures of all title compounds have been confirmed on the basis of their analytical, IR and NMR spectral data. The title compounds have been tested for antibacterial activities against different strains of bacteria. Keywords: Oxazolo Pyrimidine, Antibacterial Activity, Biginelli Reaction. I. INTRODUCTION Organic chemistry has its own descent in the study of natural products. This still remains the most important role in our life and whole world. Many organic compounds occur naturally. Their functions are often of fundamental importance to living organisms. In the past decades, the pyrimidine and their derivatives have attracted increasing interest in the realms of natural and synthetic organic chemistry because of their diverse therapeutic and pharmacological properties. These non- planner heterocyclic compounds have medicinal importance for further modification in the heterocyclic frame work. In medicinal there are not a single paper is published on the anticancer screening of compounds. “DRUG DESIGN” requires the knowledge of the structure of a drug molecule as well as that of receptor molecule involved in drug receptor interaction. The structure of a molecule is responsible for its biological activities as the small change in the structure. Pyrimidines are among those molecules that make life possible being the building blocks of DNA and RNA. Several analogs of pyrimidines have been used as compounds that interfere with the synthesis and functioning of nucleic acids e.g. Fluorouracil, which has been used in cancer treatment. Also there are some thiouracil derivatives, which produce adverse reaction in susceptible patients and are found to be more potent and less likely to produce side effects and hence are being widely used 1 . There are several other important groups of pyrimidines with medicinal uses. II. METHODS AND MATERIAL Recent Developments in the Area: The determination of structure of a molecule provides two fold benefits-it helps to modify the drug and also to synthesize a new drug as the changes in the structure are accompanied with change in the biological activity. The crystal structure studies of these series compounds are important. The new synthesis organic molecules and its biologically activity, characterizations include crystal structure determination of various organic. Dr. B. B. Baldaniya* , S. N. Chadotra