Copyright: © the author(s), publisher and licensee Technoscience Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non- commercial use, distribution, and reproduction in any medium, provided the original work is properly cited International Journal of Scientific Research in Chemistry (IJSRCH) © 2020 IJSRCH | Volume 5 | Issue 6 | ISSN : 2456-8457 63 Antimalarial Activity of Psidium guajava Leaf Extracts Akshay R.Yadav 1 *, Pravin P. Honamane 2 , Manisha D. Rajput 3 , Vidya N. Dange 4 , Kiran R. Salunkhe 5 , Dr. Sandeep R. Kane 6 , Dr. Shrinivas K. Mohite 7 1,2,3,6,7 Department of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon, Dist- Sangli, Maharashtra, India-415404 4 Department of Pharmaceutics, Rajarambapu College of Pharmacy, Kasegaon, Maharashtra, India-415404 5 Department of Pharmaceutics, Shree Santkrupa College of Pharmacy, Ghogaon, India-415111 *Corresponding author E-mail: akshayyadav24197@gmail.com Article Info Volume 5, Issue 6 Page Number: 63-68 Publication Issue : November-December-2020 Article History Accepted : 15 Nov 2020 Published : 30 Nov 2020 ABSTRACT Malaria is a major global public health problem, and the alarming spread of drug resistance and limited number of effective drugs now available underline how important it is to discover new antimalarial compounds. In the present study, Psidium guajava extracts tested for their antimalarial activity. The search for new plant-derived drugs has gained renewed interest among researchers worldwide in the hunt for new drugs that have the potential to combat the threat of drug-resistant pathogenic microorganisms, antitumor and anticancer agents. By performing antimalarial activity it was found that methanolic extract has significant antimalarial activity. Keywords: Psidium guajava, Malaria, Antimalarial activity. I. INTRODUCTION Malaria is the world’s most important tropical disease. It is prevalent in about 100 countries and around 2,400 million people are at risk 1 . In South East Asia alone, 100 million malaria cases occur every year and 70% of these are reported from India 2 . The resistance has at the same time increasingly extended to other available antimalarial drugs 3-4 . Psidiumguajavais a small evergreen tree (Myrtaceae), commonly known as guava in English, an important food crop and medicinal plant native to South America, grown in tropical and subtropical lands and also found in India 5-7 . Microwave extraction has proved to be more effective and efficient than its conventional counterpart, the soxhlet extraction method. The Soxhlet extraction, which is a standard technique, is a continuous solvent extraction method. Extraction systems are used to conduct routine solvent extractions of soils, sediments, sludge, polymers and plastics, pulp and paper, biological tissues, textiles and food samples 8-13 . Experiments have proved that microwaves, in comparison with the soxhlet extraction, use a lesser volume of solvent and sample