Volume 4, Issue 11, November – 2019 International Journal of Innovative Science and Research Technology ISSN No:-2456-2165 IJISRT19NOV384 www.ijisrt.com 355 The Microwave Assisted Rapid and Efficient Synthesis of Azlactones Amit P.Tayade *1 , Ramkrushna P. Pawar 2 , Rajiv V. Khobare 3 , Chandakant B.Mane 4 , and Nitin P. Tayde 5 . 1,3 Department of chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad (MS) 431004 2 Department of chemistry, Govt. Vidarbha Institute of Science and Humanities, Amravati (MS) 444604 4 Department of chemistry, shri Vijaysinha Yadav Arts & Science college, pethvadgaon Dist Kolhapur (MS) 5 Department of chemistry, Anuradha Engineering College, ChikhliI Dist Buldhana (MS)43201 Abstract:- A simple and extremely fast and high yielding protocol gives the azlactone under microwave irradiation. azlactone reaction offers the simple workup, high yield, easy and simple purification and economically available catalyst . Keywords:- Sodium Hypophosphite, Benzoylaminoethanoic Acid, Aldehyde, Microwave, Green. I. INTRODUCTION Heterogeneous catalysts are always prominent over the homogenous counterparts in terms of environmental friendly, easy and simple in operation to get better result. In recent time green approach of synthesis with solvent free medium or solvent medium, heterogeneous solid acid-base catalysts, nanopartical have received more importance in organic transformations. The uses of simple, cheap and easily available non hazardous catalyst help formation of high yield. Now a day One pot synthesis approaches has open new arena for the development of quick and efficient target complex synthesis. Furthermore heterocyclic systems exhibit wide range of significant pharmaceutical properties. An oxazoles and oxazolones are important scaffold in drug discovery; it contains N and O in five member ring Oxazolone and its derivatives are show wide use in medical and pharma industry. Oxazol are imp intermediates in the synthesis of antimicrobial or anti inflammatory compound. In 1893 F. Erlenmeyer introduced the Erlenmeyer synthesis when aldehyde react with N-acetylgycine and acetic anhydride with small amount of sodium acetate ,a simple condensation reaction gives azlactones [ 1]. Recently some new catalyst compound include such as ZnO [2 ], (NH4)2HPO4[3 ], ZnCl2 [4 ], Al2O3[ 16 ] etc, but above method having problem such as hazardous material , long reaction time and low yield The microwave dielectric heating shows its utility in synthesis , to accelerate the organic reaction. This method is more effective then thermal heating. It improve the purity of product also enhance the chemical yield in short reaction time. In this paper we are using sodium hypophosphite as catalyst under solvent free condition using microwave process. II. EXPERIMENTAL  Experimental Section All chemical were purchased from Merck, sdfcl were commercially available and were used as received without further purification. The melting points were measured by open capillary method incorrectly. IR data collected on (range 4000-400) ). NMR Data recorded in DMSO –d6 as solvent by Bruker Avance Neo 500 MHz spectrometer. The reaction were carried out in a domestic microwave oven (onida-MO 20CJS26S) at 800 watt.  General Procedure Foe the Synthesis of Azolactone The appropriate aldehyde (1mmol), Benzoylaminoethanoic acid (1.1 mmol) , acetic anhydride (3.3.mmol) and sodium hypophosphite (5 mol %) were taken in Erlen Meyer flask i.e.conical flask capped with funnel. After that flask placed in a microwave oven and it irradiated at 260 watts for 4- 6 min.(table -1) After irradiation , the mixture was cooled to room temperature and then it wash with cold water. Finally the crude product was recrystalized from 95 % ethanol, gives yellow solid precipitated known as azlactone.