Journal of Crystal and Molecular Structure, Vol. 8, No. 4, 1978
Crystal structure of 2-chloroacetamide
form): A reinvestigation
B. KALYANARAMAN, L. D. KISPERT, * AND J. L. ATWOOD
Department of Chemistry
The University of Alabama
Tuscaloosa, Alabama 35486
(ReceivedApril 28, 1978)
Abstract
The crystal structure of the ~ form of 2-chloroacetamide, grown by sUb-
limation, has been determined from three-dimensional counter data and
refined by full-matrix least-squares techniques. The crystals belong to the
monoclinic space group P21/c with a = 10.263(8), b = 5.142(5), c =7.458(6) ~,
/3=98.72(4)°, and D~=l.60 gcm -a for Z=4. The final R factor for 518
observed reflections is 0.037. The molecule exists as a hydrogen-bonded
dimer in the crystal structure. The configuration of atoms C(1), C(2), O,
and N is planar to within 0.008 AI, and the CI-C(1)-C(2)-O dihedralangle
equals 168 ° . The dimeric hydrogen bonding as well as the CH2 conformation
favors the stabilization of a transient oxygen-centered radical.
Introduction
As part of a general ESR study of the radicals formed in irradiated crystals
of carboxylic acids and amides, it was noted that an oxygen-centered
n radical, was present in irradiated 2-chloroacetamide at 77 K that
was not detected in irradiated 2-chloroacetic acid (Kalyanaraman and
Kispert, 1978). Based on previous studies of irradiated carboxylic acid, this
result seemed inconsistent since similar radicals should have been formed
(Iwasaki, 1972). Assuming the difference to originate in the crystal structures
of the two compounds, the crystal structure of the stable form of 2-chloro-
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0308-4086/7810800-0175 $ 05.00 [0 © 1979 Plenum Publishing Corporation