Copyright: © the author(s), publisher and licensee Technoscience Academy. This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non- commercial use, distribution, and reproduction in any medium, provided the original work is properly cited International Journal of Scientific Research in Science and Technology Print ISSN: 2395-6011 | Online ISSN: 2395-602X (www.ijsrst.com) doi : https://doi.org/10.32628/IJSRST207667 7 Synthesis, Characterization and Biological Active 2 (Dimethylamino) Cyclohexane-1, 3-Dione Veerappan Jeyachandran Department of Chemistry, Bharath Institute of Higher Education and Research, Selaiyur, Chennai, Tamil Nadu, India Corresponding author e-mail: jeyorg@gmail.com Article Info Volume 8, Issue 1 Page Number: 07-09 Publication Issue : January-February-2021 Article History Accepted : 01 Jan 2021 Published : 04 Jan 2021 ABSTRACT In the present work, the precursors 2- ( ( dimethylamino ) methylene ) cyclohexane-1,3-dione 4 and 2- ( ( dimethylamino ) methylene ) -5, 5- dimethylcyclohexane-1,3-dione 5 were synthesized from the reaction of 1,3- cyclohexanedione 1 or 5,5-dimethyl-1,3-cyclohexandione 2 with DMF-DMA 3, respectively following literature procedure (Scheme 1). Seheme 1. Synthesis of precursors 4, 5 Keywords : Pyrazoles, Dimethylamino, Cyclohexane and Alkaloids. I. INTRODUCTION Pyrazoles are five-member ring heterocyclic compounds, consisting of a doubly unsaturated five membered ring with two adjacent nitrogen atoms and are also called as azoles. These are aromatic molecules due to their planar conjugated ring structures with six delocalized π-electrons [1]. The term pyrazole was given by Ludwig Knorr in 1883. Being so composed and having pharmacological effects on humans, they are classified as alkaloids, although they are rare in nature. In 1959, the first natural pyrazole, β-[1- pyrazolyl] alanine was isolated from the seeds of water melons [Citurllus lanatus] [2]. Literature survey has revealed that till 1930s very little had been done for the synthesis of steroidal pyrazole derivatives. Several pyrazole derivatives have been found to possess significant activities such as 5-α- reductase inhibitor, [3] antiproliferative, [4] antiparasitiC [5] and herbicides [6]. pyrazolo[1,5-a] quinoline derivatives have been developed for dopamine D4 antagonist agents,[7] GPR109a agonist agents [8] and organic light-