Treviño-Becerra A, Iseki K (eds): Uric Acid in Chronic Kidney Disease. Contrib Nephrol. Basel, Karger, 2018, vol 192, pp 125–134 (DOI: 10.1159/000484287) Abstract Background: High serum uric acid concentration (SUA >6 for women [W] or 7 mg/dL for men [M]) in adults is an independent risk factor for causing cardiovascular disease and chronic kidney disease (CKD); the risk of high SUA in young population is still being de- bated. Summary: We conducted an epidemiological study to determine the association between SUA quartiles with cardiometabolic risk factors (CRF) and renal impairment in apparently healthy young adults. CRF (dyslipidemia, overweight [Ow], obesity [Ob], blood pressure [BP], hyperglycemia, insulin resistance [IR]) and renal impairment were defined as glomerular filtration rate (GFR) by CKD-Epidemiology Collaboration formula >130/120, <90 mL/min/1.73 m 2 , and proteinuria were measured in 18- to 25-year-old students (total n = 5,531). Adjusted ORs by sex were calculated using logistic regression. Results: The mean SUA was 4.5 ± 1.04 and 6.2 ± 1.2 mg/dL in W and M respectively. High SUA was found in 13.9% ( n = 767); prevalence of Ow/Ob 69% (528 of 767), high BP 9% (67), hyperglycemia 15% (112), IR 47% (214), hypertriglyceridemia 35% (269), high LDL-c 16% (120), low HDL- c 52% (399), and metabolic syndrome 33% (249). Prevalence of high GFR was 13% (103), low GFR 8% (62) and proteinuria 5% (37). All risk factors showed a positive relationship with the SUA quartiles with high LDL-c with lowest risk (OR 1.7) and Ow/Ob with highest risk (OR 4.1), independent of sex. Key Messages: High SUA concentrations (M ≥6.2/W ≥4.5 mg/dL) are associated with CRF and renal impairment in young adults. It is necessary to reevaluate the cutoff points for UA in young adults. © 2018 S. Karger AG, Basel Clinical Significance of Serum Uric Acid Levels in Mexican Young Adults Araceli Alegría-Díaz a · Rafael Valdez-Ortiz a · Miguel Murguía-Romero b, c · Rafael Jiménez-Flores b, c · Rafael Villalobos-Molina b, c · Srinivas Mummidi d · Ravindranth Duggirala d · Juan C. López-Alvarenga d, e · Monserrat Pérez-Navarro a a Department of Nephrology, Hospital General de México, México City, b Iztacala School of Graduate Studies, National Autonomous University of Mexico (FES-I. UNAM), Tlalnepantla, c National Laboratory in Health: Molecular Diagnosis and Environmental Effect in Chronic-Degenerative Diseases, National Autonomous University of Mexico (UNAM), Tlalnepantla, México; d South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley, Edinburg, TX, USA; e Universidad Mexico Americana del Norte, Reynosa Tamaulipas, México Downloaded by: UCL 144.82.238.225 - 2/6/2018 6:02:26 AM