Romanian Reports in Physics, Vol. 66, No. 1, P. 175–181, 2014 THE RESULTS OF COMBINATION OF IFOSFAMID AND LOCOREGIONAL HYPERTHERMIA (EHY 2000) IN PATIENTS WITH ADVANCED ABDOMINAL SOFT-TISSUE SARCOMA AFTER RELAPSE OF FIRST LINE CHEMOTHERAPY * SIMONA RUXANDRA VOLOVAT 1 , CONSTANTIN VOLOVAT 2 , VIOREL SCRIPCARIU 1 , CRISTIAN LUPASCU 3 , LUCIAN MIRON 1 1 Regional Institute of Oncology, Iasi, Gral Henry Mathias Berthlot Str. no. 2-4, Iasi, Romania E-mail: simona_v2002@yahoo.com 2 Euroclinic Oncology Center, Iasi, Vasile Conta str., no. 2, Iasi, Romania E-mail: constantin.volovat@victoria-hospital.ro 3 Emergency County Hospital Sf. Spiridon, Iasi, Vasile Conta str., no. 2, Iasi, Romania Received April 23, 2013 Abstract. From 2003 to 2011, 24 patients with advanced soft-tissue sarcoma with high- risk pretreated using first line chemotherapy with doxorubicin and recurrence disease were treated with chemotherapy (ifosfamide 3000mg/sqm, day 1–3) and locoregional hyperthermia (1 hour application with temperature between 41.5°C and 42°C, 3 days/week). The purpose was to evaluate the efficacy and safety of chemotherapy combined with locoregional non-invasive hyperthermia for local tumor control in patients with retroperitoneal or visceral advanced soft tissue sarcomas. From 24 patients, 18 patients have had an evaluable response on CT scan using RECIST 1.0 (stable disease 8 patients for 4 months and 1 patients for 1 month, partial response 8 patients for 4 months, progression disease for 1 patient). The response was mainly on local tumor site. The side effects were correlated only with chemotherapy (neutropenia grade III 40%, grade 4 20%, trombocytopenia 2%, anemia grade III 10%, neurologic toxicity 9%). No toxicity was correlated with hyperthermia treatment. Key words: soft-tissue sarcoma, chemotherapy, locoregional hyperthermia. 1. INTRODUCTION Soft tissue sarcoma prognosis factors are high grade histology results, large tumor size (>5cm) and deep localization [1]. If median overall survival for the * Paper presented at the 1 st Annual Conference of the Romanian Society of Hadrontherapy (ICRSH 2013), February 21–24, 2013, Predeal, Romania.