IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) e-ISSN: 2279-0853, p-ISSN: 2279-0861.Volume 20, Issue 4 Ser.4 (April. 2021), PP 13-18 www.iosrjournals.org DOI: 10.9790/0853-2004041318 www.iosrjournal.org 13 | Page “Comparison of Fentanyl with Dexmedetomidine on attenuating the haemodynamic response to intubation: A randomized double blind clinical study”. Dr Amit Kumar Sahu 1 , Dr Koshy Varghese 2 , Dr Asif Ahmed 3 , Dr Shyam Sundar Sahu 4 1 DNB Anaesthetist 2,3Specialist 4 Assistant professor 1,2,3 Deptt of Anaesthesia and Critical Care, Tata Main Hospital, Jamshedpur, India 4 Deptt of Paediatric Surgery, RIMS , Ranchi, India Abstract:- Aim: To compare the effect of intravenous Fentanyl with intravenous Dexmedetomidine on haemodynamic response to laryngoscopy & tracheal intubation in patients posted for elective surgical procedures and to study the safety and side effects of these drugs. Settings and Design: Prospective, randomized & double blind study. Methods and Material: 100 elective surgical patients of aged 18 to 65 years were included in study. All patients underwent elective surgical procedures under general anaesthesia. Patients were randomized into two groups. Group F: Received Fentanyl 2μg/kg, Group D : Received Dexmedetomidine 1μg/kg. The following parameter (HR, SAP, MAP, DAP, and SpO2) levels were measured and recorded: - Average of three readings taken in operation theatre were considered as baseline and all other measurements were compared with the baseline. Statistical analysis used: All data were calculated as mean, standard deviation, percentage, Comparison of two mean tests and Chi-square test used Results: When basal levels were compared with the measurements of the groups, it was found that during laryngoscopy and subsequent time intervals post intubation heart rate, systolic, diastolic, mean arterial pressures in Group D were lower than Group F. Conclusions: Dexmedetomidine was superior then Fentanyl in the prevention of tachycardia. Dexmedetomidine also prevented systolic, diastolic, mean arterial pressure increases following intubation better than fentanyl. Key word- Dexmedetomidine, Fentanyl, randomization, laryngoscopy, intubation --------------------------------------------------------------------------------------------------------------------------------------- Date of Submission: 22-03-2021 Date of Acceptance: 06-04-2021 --------------------------------------------------------------------------------------------------------------------------------------- I. Introduction Laryngoscopy and endotracheal intubation form the basic integral part of balanced anaesthesia wherein the airway is secured and controlled ventilation can be administered to the patient. However, undesired haemodynamic fluctuations are encountered with laryngoscopy and endotracheal intubation. These changes are especially in the form of an increase or decrease in heart rate, arterial blood pressure and myocardial oxygen demand along with cardiac rhythm disturbances 1 , which were demonstrated as early as 1940s & 1950s 2 .