This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1002/cnm.2794 This article is protected by copyright. All rights reserved. TITLE PAGE Full title The Role of Infarct Transmural Extent in Infarct Extension: A Computational Study Authors’ names, academic degrees, and affiliations Chin-Neng Leong, BEng 1,2 , Einly Lim, PhD 1 , Andri Andriyana, PhD 3 , Amr Al Abed, PhD 2 , Nigel Hamilton Lovell, PhD 2 , Christopher Hayward, MBBS, PhD 4 , Christian Hamilton-Craig, MBBS, PhD, FACC 5 , Socrates Dokos, PhD 2 1 Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia. 2 Graduate School of Biomedical Engineering, UNSW, Sydney, NSW 2052, Australia. 3 Department of Mechanical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia. 4 St Vincent’s Hospital, Sydney; UNSW, Sydney; Victor Chang Cardiac Research Institute, Sydney, NSW, Australia. 5 Centre for Advanced Imaging, University of Queensland, Brisbane, QLD, Australia; University of Washington School of Medicine, Seattle WA, USA. Corresponding author Name: Einly Lim Address: Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, 50603 Kuala Lumpur, Malaysia. Fax Number: +603-79560027 Telephone Number: +603-79677612 Email: einly_lim@um.edu.my Acknowledgements We would like to thank Chee Kok Han, Yang Faridah Abdul Aziz, Shahrul Amry Hashim, and Liew Yih Miin, PhD, for providing valuable consultation, as well as Chan Bee Ting, MS, for helping in construction of the computational models. ABSTRACT Infarct extension, a process involving progressive extension of the infarct zone (IZ) into the normally perfused border zone (BZ), leads to continuous degradation of the myocardial function and adverse remodeling. Despite carrying a high risk of mortality, detailed understanding of the mechanisms leading to BZ hypoxia and infarct extension remains unexplored. In the present study, we developed a 3D truncated ellipsoidal left ventricular (LV) model incorporating realistic electromechanical properties and fiber orientation to examine