Freely Available Online www.openaccesspub.org | JESR CC-license DOI : 10.14302/issn.2574-4372.jesr-14-607 Vol-1 Issue 1 Pg. no.- 1 JOURNAL OF EVOLVING STEM CELL RESEARCH ISSN NO: 2574-4372 REVIEW Evaluating Circadian Oscillators in Cancer Stem Cells Michael E. Geusz 1* , Vishal P. Sharma 1 , Ashapurna Sarma 1 Astha Malik 1 Bowling Green State University, Dept. of Biological Sciences, Bowling Green, OH 43403 Abstract Cancer is influenced by the ability of cells to maintain circadian rhythms in molecular and metabolic processes. Disturbance of the underlying circadian timing mechanism in circadian clock cells leads to a higher frequency and more rapid progression of cancer. Cancer stem cells with properties of embryonic and somatic stem cells have been implicated as tumor initiators in several types of cancers. Although tumors are reported to have disorganized circadian rhythms, evidence of in vitro circadian rhythms in cancer stem cells of gliomas was recently presented. The possibility and consequences of circadian clocks functioning in cancer stem cells within tumors is examined, and the possible benefits to these cells from circadian timing is discussed in relation to cancer treatments. DOI : 10.14302/issn.2574-4372.jesr-14-607 Corresponding Author: Michael E. Geusz, Ph.D. Associate Professor Dept. of Biological Sciences, Bowling Green State University 217 Life Sciences Bldg., Bowling Green, OH 43403 419-372-2433, mgeusz@bgsu.edu Running title: Circadian clocks and cancer stem cells Key Words: cancer stem cell, circadian rhythm, chronotherapy, tumorigenesis Received August 31 2014; Accepted March 11 2015; Published June 01 2015;