REV.CHIM.(Bucharest)♦70♦No. 2 ♦2019 http://www.revistadechimie.ro 659 Evaluation of Echocardigraphic Parameters in Patients with Rhythm Disorders Associated with Chronic Hepatic Diseases VERONICA CALBOREAN 1 , ION UDRISTOIU 2 *, ANDREEA DENISA DOCEA 3 , MIHAI CRISTIAN HODOROG 4 , SORIN NICOLAE DINESCU 5 , OANA CRICIOTOIU 6 , DIANA STANCA 6 , ADRIAN MITA 7 , DRAGOS VIRGIL DAVITOIU 8 , VLAD DUMITRU BALEANU 9 , FLORIN MARIUS ROMANESCU 10 , MARIUS BICA 11 , CECIL SORIN MIREA 11 , VENERA CRISTINA DINESCU 12 1 University of Medicine and Pharmacy of Craiova, Cardiology Department, 2 Petru Rares Str., 200349, Craiova, Romania 2 University of Medicine and Pharmacy of Craiova, Psychiatry Department, Neuropsychiatry Hospital of Craiova, 24 Aleea Potelu Str., 200473, Craiova, Romania 3 University of Medicine and Pharmacy of Craiova, Gynecology Department, 2 Petru Rares Str., 200349, Craiova, Romania 4 University of Medicine and Pharmacy of Craiova, Department of Urology, 2 Petru Rares Str., 200349, Craiova, Romania 5 University of Medicine and Pharmacy of Craiova, Epidemiology and Primary Health Care Department, 2 Petru Rares Str.,200349, Craiova, Romania 6 University of Medicine and Pharmacy of Craiova, Neurology Department, Neuropsychiatry Hospital of Craiova, 99 Calea Bucuresti Str., 200473, Craiova, Romania 7 University of Medicine and Pharmacy of Craiova, Internal Medicine Department, Filantropia Hospital of Craiova,1Filantropiei Str., 200143, Craiova, Romania 8 University of Medicine and Pharmacy of Bucharest, Surgery Department, Clinical Emergency Hospital Sf. Pantelimon Bucharest, 340-343 Pantelimon Road, 021659, Bucharest, Romania 9 University of Medicine and Pharmacy of Craiova, Surgery Department, Clinical Emergency Hospital Sf. Pantelimon Bucharest, 340-343 Pantelimon Road, 021659, Bucharest, Romania 10 University of Medicine and Pharmacy of Craiova, Department of Physiology, 2 Petru Rares Str., 200349, Craiova, Romania 11 University of Medicine and Pharmacy of Craiova, Surgery Department, 2 Petru Rares Str., 200349, Craiova, Romania 12 University of Medicine and Pharmacy of Craiova, Health Promotion and Ocupational Medicine Department, 2 Petru RaresStr., 200349, Craiova, Romania Due to the increased frequency of cardiovascular diseases in the evolution of chronic liver disease, we proposed to assess echocardiographic changes in patients with rhythm disorders associated with chronic liver disease. To analyze the degree of cardiac damage, each patient was subjected to a complete cardiovascular examination. Keywords: hepatic disease, echocardiographic examination, cardiac affectation * email: cp1@psycv.ro; Phone: 0251426020 All authors made equal contribution to the paper, to that of the first authors Rhythm disorders refer to the abnormality or disturbance of the normal myocardial activation sequence [1-6]. This indicate structural cardiac disease and may be the cause of significant cardiovascular complications and sudden cardiac death [5-11]. Regardless of its etiology spectrum, the hepatic disease leads changes in the structure and functions of the heart, mostly with latent, infra-clinically progression, often recognized by clinicians with difficulty [12-15]. Cardiovascular diseases are one of the leading causes of death in the world[16-17]. Rhythm disordes are associated with increased morbidity and mortality [18-19]. The association between chronic hepatic disease and rhythm disorders cause additional comorbidities [20-24]. Early recognition of the underlying causes of cardiovascular disease, of the clinical and para-clinical test and the modifiable risk factors, determine its rate of progression and focus on preventive treatment and possible complications of the chronic hepatic disease [21-24]. The diversity of the etiological factors of chronic liver disease involves investigating each aspect of the arrhythmogenic substrate and assessing its triggering and aggravating factors in order to obtain a diagnosis of high probability and practical utility. Experimental part The aim of the study In our study, 126 patients were diagnosed based on the clinical and para-clinical tests with chronic hepatic disease and 120 patients without chronic liver disease, representing the control group. The study was conducted over a period of 14 months, from 1.10.2016 to 1.01.2018 The purpose of our study was to assess the echocardiographic parameters in patients with rhythm disorders associated with chronic hepatic disease . We have correlated different signs of cardiac damage, those characteristic of systolic and diastolic dysfunction with the etiology of chronic liver disease. To analyze the degree of cardiac damage, each subject in our research (study lot plus control lot) was subjected to a complete cardiovascular examination: - Anamnesis and clinical examination of the cardiovascular system, with evaluation of positive signs and symptoms, specific to heart disease - Echocardiography for the evaluation of cardiac changes. We studied left ventricular function, left ventricular diameters both in systole and diastole, left ventricular posterior wall, right ventricle, right atrium, left atrium, and interventricular septum. Results and discussions The echocardiographic examination was influenced by a number of factors. These include obesity, pulmonary emphysema, altered somatic status, psychomotor restlessness and agitation so frequently encountered in patients with cardiac impairment [25].