Society Proceedings The British Society for Clinical Neurophysiology, London, 11th October 2002 Hon. Meetings Secretary : Dr D.A. Ingram * The Royal London Hospital, Whitechapel, London, E1 1BB, UK Pudendal somatosensory evoked potential (SSEP) and quantitative sensory testing (QST) in women with female sexual dysfunction (FSD) and multiple sclerosis (MS)—G. Kanabar, R. DasGupta, C. Fowler (National Hospital for Neurology and Neurosurgery, London, UK) FSD is a common but under-diagnosed problem for women with MS. Both pudendal SSEP and genital QST (vibratory and thermal threshold tests) have been proposed as useful tools for assessing neurogenic FSD. We assessed the relation- ship between tibial and pudendal SSEP, genital QST and extent of FSD. We recruited women with symptoms of FSD related to onset of MS within a trial studying the efficacy of Viagra(Ò) in this group. All subjects completed a validated sexual function ques- tionnaire (SFQ). Pudendal and bilateral tibial SSEPs were per- formed by a single investigator, blinded to the SFQ scores. Subjects also underwent vibratory, warm and cold threshold testing. Of the 19 subjects recruited, 16 had and SFQ score below 87/ 121, suggesting abnormal sexual function. Pudendal and tibial SSEPs were abnormal in 11, normal in 5 and absent in 3. There was good correlation between pudendal and tibial SSEPs, but not between QST findings or SFQ score. Tibial SSEP can be used as a predictive test for cases where abnormal pudendal somatosensory innervation is suspected. However, there was no direct correlation with the extent of sexual dysfunction or with QST. doi:10.1016/j.clinph.2006.07.196 Age-related changes in the human albino uncrossed visual pathway—M.M. Neveu 1 , G. Jeffery 2 , L.C. Burton 1 , J.J. Sloper 1 , G.E. Holder 1 ( 1 Moorfields Eye Hospital, London, UK, 2 Institute of Ophthalmology, London, UK) Objective: The uncrossed visual pathway in albinism is reduced relative to the crossed. This study examines age-related changes in the VEPs of human albinos compared with normal subjects. Methods: Fifty-eight albino and 34 normal subjects were exam- ined. Five channel VEPs were recorded to flash (FVEP) and pat- tern appearance (PappVEP) stimulation. The amplitude and latency of the responses were analysed. Results: The contralateral FVEP amplitude of young albino subjects decreased with age, whereas that in the ipsilateral hemi- sphere increased with age. Both hemispheres differed significantly from normal, but normalised with age. The PappVEP latency in the contralateral hemisphere of young albinos decreased with age, whereas that for the ipsilateral hemisphere increased with age. Both hemispheres differed significantly from normal. The PappVEP latency in the contralateral hemisphere normalised with age, but that in the ipsilateral hemisphere continued to increase. Conclusion: VEP sensitivity changes with age. FVEP abnor- malities present early in development and normalise with age, whereas PappVEP abnormalities persist during adulthood. The results suggest significant maturational changes in the uncrossed pathway of the human albino. doi:10.1016/j.clinph.2006.07.197 Phenotypic variations in enhanced S-cone syndrome—G.E. Holder, C.R. Hogg, M.M. Neveu, A.G. Robson, A.C. Bird (Moorfields Eye Hospital, London, UK) Enhanced S-cone syndrome (ESCS) is a very rare genetically determined disorder, related to mutation in NR2E3, first described in 1990. The diagnosis is established by pathognomonic ERG changes: the ISCEV Standard photopic single flash and sco- topic maximal responses have similar waveform, with ERGs max- imally sensitive to short wavelength stimulation. A single histopathological report determined a retina devoid of rods, and doi:10.1016/j.clinph.2006.07.195 www.elsevier.com/locate/clinph Clinical Neurophysiology 118 (2007) e137–e140