Clinical Pharmacology and Therapeutics 1 Pharmacogenomics of human uridine diphospho-glucuronosyltransferases (UGTs) and clinical implications Chantal Guillemette 1,3 , Éric Lévesque 2 and Michèle Rouleau 1 Pharmacogenomics Laboratory, Centre Hospitalier de l’Université Laval (CHU) de Québec Research Center and 1 Faculty of Pharmacy and 2 Faculty of Medicine of Laval University, G1V 4G2, Quebec, Canada; 3 Canada Research Chair in Pharmacogenomics. Short Title: UGT pharmacogenomics in drug metabolism and diseases Key words: Glucuronidation, UGT, Pharmacogenomics, Drug metabolism, Drug toxicity, Polymorphisms, Cancer susceptibility and progression, Alternative splicing, Epigenetic. Author to whom correspondence should be sent: Chantal Guillemette, Ph.D. Canada Research Chair in Pharmacogenomics Pharmacogenomics Laboratory CHU de Québec Research Center 2705 Boul. Laurier, R4720 Québec, Canada, G1V 4G2 Tel. (418)654-2296; Fax.(418)654-2761 E-mail: Chantal.Guillemette@crchul.ulaval.ca