Research Article Efficacy and Safety of Sahastara Remedy Extract Capsule in Primary Knee Osteoarthritis: A Randomized Double-Blinded Active-Controlled Trial Narin Kakatum , 1 Piya Pinsornsak , 2 Puritat Kanokkangsadal , 3,4 Buncha Ooraikul , 5 and Arunporn Itharat 3,4 1 Student of Doctor of Philosophy (Applied ai Traditional Medicine) Faculty of Medicine, ammasat University, Bangkok, Pathum ani, ailand 2 Department of Orthopedics, Faculty of Medicine, ammasat University, Bangkok, Pathum ani, ailand 3 Department of Applied ai Traditional Medicine, Faculty of Medicine, ammasat University, Klongluang, Bangkok, Pathum ani, ailand 4 Center of Excellence on Applied ai Traditional Medicine Research (CEATMR), Faculty of Medicine, ammasat University, Klongluang, Bangkok, Pathum ani, ailand 5 Department of Agricultural Food and Nutritional Science, Faculty of Agricultural Life and Environmental Sciences, University of Alberta, Alberta T6G 2P5, Edmonton, Canada Correspondence should be addressed to Arunporn Itharat; iarunporn@yahoo.com Received 25 October 2020; Revised 5 January 2021; Accepted 7 January 2021; Published 18 January 2021 Academic Editor: Wei Lei Copyright © 2021 Narin Kakatum et al. is is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Sahastara (SHT) remedy is a ai traditional medicine described in the ai National List of Essential Medicine (NLEM) for the relief of muscle pain. e purpose of this study was to investigate the efficacy and safety of SHTremedy extract capsule for treating primary OA. A phase 2, double-blind, randomized, and controlled trial study was used to determine the clinical efficacy and safety of SHT in comparison with diclofenac for the treatment of knee OA. e outcome of reduce pain was measured from VAS, 100 meter time walk, and the WOMAC score of day 14 and day 28 which should reduce significantly when compared with day 0 and should be equal with or better than diclofenac. Blood pressure and blood chemistry values at day 14 and day 28 did not change when compared with day 0. e results found that SHTremedy ethanolic extract capsule can reduce all OA knee scores at day 14 and day 28 significantly when compared with day 0 and also no significant difference with diclofenac (P > 0.05). e SHTalso showed safety values on blood pressure and blood chemistry. e SHTwas observed that it had no serious side effect. e results of this study are the first report of using the SHTethanolic extract capsule in the treatment of primary osteoarthritis of the knee. It can be recommended as an anti-inflammatory herbal drug for reducing pain in knee osteoarthritis patients. 1.Introduction Osteoarthritis (OA) is the most common joint disease whichoccursmorefrequentlyinmalesbeforetheageof45 and more frequently in females after 55 years of age. Osteoarthritis commonly occurs in the hands, feet, spine, and large weight-bearing joints, such as hips and knees. OA with no known cause is referred to as primary os- teoarthritis. When the cause is known, it is referred to as secondary osteoarthritis. Cartilage changes when the dynamics of biology, biochemistry, and bone structure around it changed. In the elderly, involvement of synovial fluid is most common. e pain is an important clinical complaint [1]. e oral and topical NSAIDs are most commonly used to relieve pain in OA knee patients. Diclofenac was used as an active control which showed a superior effect for osteoarthritis [2]. Not only NSIADs were used for OA treatment but alternative medicine was also commonly used, including acupuncture, ai mas- sage, sesame oil, yellow oil, and herbal medicine [3–5]. Hindawi Evidence-Based Complementary and Alternative Medicine Volume 2021, Article ID 6635148, 10 pages https://doi.org/10.1155/2021/6635148