_____________________________________________________________________________________________________ *Corresponding author: E-mail: mussyballow@yahoo.com; European Journal of Medicinal Plants 31(10): 152-160, 2020; Article no.EJMP.58512 ISSN: 2231-0894, NLM ID: 101583475 Conservation of a Rare Medicinal Plant: A Case Study of Griffonia simplicifolia (Vahl ex DC) Baill Musibau Muyiwa Balogun 1,2* , Muhali Olaide Jimoh 3,2 and Oluwatoyin Temitayo Ogundipe 2 1 Lagos State Centre for Rural Development (CERUD), Itoikin-Epe Road, Igbodu, Epe Division, Lagos State, Nigeria. 2 Department of Botany, University of Lagos, Akoka, Lagos State, Nigeria. 3 Department of Botany, University of Fort Hare, Alice 5700, South Africa. Authors’ contributions This work was carried out in collaboration among all authors. Author MMB designed the study, performed the statistical analysis, wrote the protocol and wrote the first draft of the manuscript. Author MOJ managed the literature searches, analyzed the data obtainedin the study, edited and prepared the manuscript. Author OTO conceived, designed and supervised the experiment.All authors read and approved the final manuscript. Article Information DOI: 10.9734/EJMP/2020/v31i1030291 Editor(s): (1) Dr. Francisco Cruz-Sosa, Metropolitan Autonomous University, Mexico. (2) Prof. Marcello Iriti, University of Milan, Italy. Reviewers: (1) Subramanian Chandrodyam, University of Gondar, Ethiopia. (2) Hari Shankar Lal, Jharkhand Biodiversity Board, India. Complete Peer review History: http://www.sdiarticle4.com/review-history/58512 Received 28 April 2020 Accepted 03 July 2020 Published 27 July 2020 ABSTRACT This study aimed at carrying out the vegetative propagation of Griffonia simplicifolia. This was achieved by growing nodal and stem cuttings of G. simplicifolia using two types of soils under varying environmental conditions including open area and humidity propagator. This revealed that terminal nodal stem cuttings showed the best growth forms in terms of shoot development as well as root development when subjected to open area and topsoil. However, when subjected to the humid propagator and river sand, the distal stem cuttings gave the best growth forms thereby promoting shoot and root development. Hence, it is concluded that the terminal nodes are the best parts to be used for the propagation of G. simplicifolia and the best growth medium is river sand. Furthermore, this research demonstrates that G. simplicifolia can be reproduced through macro propagation using stem cuttings and it can be seen as a basis for conservation and other breeding research on G. simplicifolia. Original Research Article