REV.CHIM.(Bucharest)♦69♦No. 6 ♦2018 http://www.revistadechimie.ro 1527 Correlation Between Liver Cirrhosis and Risk of Cardiac Arrhythmias VERONICA CALBOREAN 1 , SILVIA ALINA MISCOCI 2 *, OCTAVIAN ISTRATOAIE 1 , OANA GALCEAVA 3 , DRAGOS OVIDIU ALEXANDRU 4 , MARIA MANUELA GUTA 5 , VICTOR GHEORMAN 6 , VLAD PADUREANU 2 , CATALIN MIRCEA FORTOFOIU 7 , ANDA LORENA DIJMARESCU 8 , DAN IONUT GHEONEA 9 1 University of Medicine and Pharmacy of Craiova, Cardiology Department, County Hospital Craiova, 1 Tabaci Str., 200642, Craiova, Romania 2 University of Medicine and Pharmacy of Craiova, Internal Medicine Department, County Hospital of Craiova, 1 Tabaci Str., 200642, Craiova, Romania 3 University of Medicine and Pharmacy of Craiova, Neurology Department, Neuropsychiatry Hospital of Craiova, 99 Calea Bucuresti Str., 200473, Craiova, Romania 4 University of Medicine and Pharmacy of Craiova, Department of Medical Informatics and Biostatistics, 66 1 Mai Blvd, 200638, Craiova, Romania 5 University of Medicine and Pharmacy of Craiova, Department of Otorhinolaryngology, 1 Tabaci Str., 200642 ,Craiova Romania 6 University of Medicine and Pharmacy of Craiova, Psychiatry Department, Neuropsychiatry Hospital of Craiova, 99 Calea Bucuresti Str., 200473, Craiova, Romania 7 University of Medicine and Pharmacy of Craiova, Internal Medicine Department, Filantropia Hospital of Craiova,1 Filantropiei Str., 200143, Craiova, Romania 8 University of Medicine and Pharmacy of Craiova, Obstetrics-Gynecology Department, Filantropia Hospital of Craiova, 1 Filantropiei Str., 200143, Craiova, Romania 9 University of Medicine and Pharmacy of Craiova, Gastroenterology Department, County Hospital of Craiova, 1 Tabaci Str., 200642, Craiova, Romania There are few studies analyzing the correlation between liver cirrhosis and cardiac arrhythmias. Still, factors triggering cardiac arrhythmias occur in many instances in liver cirrhosis.We studied a cohort with patientsdiagnosed with liver cirrhosis hospitalized to Cardiology Department, to the County Hospital of Craiova, between January 2017 and January 2018. We wanted to study the frequency of cardiac arrhythmias at the patients diagnosed with liver cirrhosis and also to evaluate several associated factors.The frequency of cardiac arrhythmias in the presence of risk factors was analysed using x 2 test and statistical models.We analized multiple variable including demographics and clinical and biochemical characteristics, frequency of type of arrhythmias and evaluation of the associated factors like diabetes mellitus, hypertension, hypercholesterolemia, hypertriglyceridemia ,hyper/hypokalemia and hyper/hyponatremia. From our group, after exclusion criteria, we have a total of 34 patients with alcoholic liver cirrhosis, 37 patients with chronic HCV infection and 36 patients with HBV infection. From 34 patients with alcoholic liver cirrhosis, 23 patients presented atrial fibrillation(67.65%), from 37 patients with chronic HCV infection 21 were diagnosed with atrial fibrillation(56.76%) and from the patients with HBV infection 19 patients were known with atrial fibrillation(52.78%).We have encounter atrial flutter at 2 patients (5.56%) with chronic HBV infection. Atrial extrasystole was found at 7 patients with chronic HBV infection (19.44%), 4 patients with chronic HCV infection (10.81%) and 1 patients with alcoholic liver cirrhosis (2.94%). Ventricular extrasystole was found at 12 patients with chronic HBV infection (33.33%), 3 patients with chronic HCV infection (8.11%) and 5 patients with alcoholic liver cirrhosis (14.71%).We have also correlate the arrhythmias with different biochemical variables from our cohort. In our study there were many association between hepatic cirrhosis and cardiac abnormalities, which is concordant to reports from literature. Compared to population without liver cirrhosis, the prevalence of arrhythmias was increased in our cohort. Key words: liver cirrhosis, arrhythmias, rhythm disorders * email: miscocialina@gmail.com; Phone :0760377327 Liver cirrhosisis a public health burden worldwide with a large variety of clinical manifestations and complications, some of those can be life-threatening [1]. The term of cirrhosis can be described byhistological point of view like a diffuse liver process. These structural changes represent the results of fibrosis which has a prolonged evolution over months and years and which are converting the normal hepatic architecture into abnormal nodules[2]. Liver cirrhosis has been associated with a couple of cardiovascular complications including hemodynamic changes, hypertension and myocardial dysfunctions. All of these symptoms can develop a serious cirrhotic cardiomyopathy. The patients diagnosticated with liver cirrhosis could have various arrhythmias with both systolic and diastolic dysfunctions; they can also present chronotropic alteration and electromechanical changes [3]. In cirrhosis the cardiac dysfunction remains frequently ignored. Liver cirrhosis is correlated with a group of cardiovascular abnormalities, which include hyper dynamic circulation, portal hypertension, hepato- pulmonary syndrome and abnormal features in different vascular territories like renal and cerebral vasculature [4]. Peripheral vasodilatation secondary to a reduce cardiac after load could avert any clinical sign of cardiac dysfunction, but there are many studies which demonstrate that the ventricular systolic function could give a defective response under a physiological or pharmacological stress [5].