Frequency and phenotype of SPG11 and SPG15 in complicated spastic paraplegia (HSP) Rebecca Schüle 1,2,# ; Nina Schlipf 3,# ; Matthis Synofzik 1,2 ; Stefan Klebe 4 , Sven Klimpe 5 ; Ute Hehr 6 ; Beate Winner 7 ; Tobias Lindig 1,2 ; Andrea Dotzer 3,8 , Olaf Rieß 3 Jürgen Winkler 9 ; Ludger Schöls 1,2,* and Peter Bauer 3 1 Department of Neurology, University of Tübingen, Tübingen, Germany; 2 Research Division for Clinical Neurogenetics, Department of Neurodegenerative Disease, Hertie-Institute for Clinical Brain Research, Tübingen, Germany; 3 Department of Medical Genetics, Institute of Human Genetics, Tübingen, Germany; 4 Department of Neurology, University of Schleswig Holstein, Kiel, Germany; 5 Department of Neurology, University of Mainz, Germany; 6 Department of Human Genetics, University of Regensburg, Germany; 7 Department of Neurology, University of Regensburg, Germany; 8 Pontifical Catholic University of Paraná, Department of Health Science, Curitiba, Brazil; 9 Division of Molecular Neurology, University of Erlangen, Germany # R.S. and N.S. contributed equally to this work. Supplemental data : The supplement (2008_167528_schüle_data supplement.doc) contains detailed experimental procedures and additional clinical and genetic data. * Corresponding author: Ludger Schöls, M.D.; Department of Neurology, University of Tübingen Hoppe-Seyler-Str. 3, D 72076 Tübingen, Germany Tel.: +49 (0)7071 29 80445; Fax: +49 (0)7071 29 4839; Email: ludger.schoels@uni-tuebingen.de article word count : 1487 keywords : spastic paraplegia (174), gait disorders/ataxia (163), peripheral neuropathy (181), cognitive impairment (229), thin corpus callosum peer-00552742, version 1 - 6 Jan 2011 Author manuscript, published in "Journal of Neurology, Neurosurgery & Psychiatry 80, 12 (2009) 1402" DOI : 10.1136/jnnp.2008.167528