Journal of Biomaterials and Nanobiotechnology, 2015, 6, 267-275 Published Online October 2015 in SciRes. http://www.scirp.org/journal/jbnb http://dx.doi.org/10.4236/jbnb.2015.64025 How to cite this paper: Saif, B., Wang, C.L., Chuan, D. and Shuang, S.M. (2015) Synthesis and Characterization of Fe 3 O 4 Coated on APTES as Carriers for Morin-Anticancer Drug. Journal of Biomaterials and Nanobiotechnology, 6, 267-275. http://dx.doi.org/10.4236/jbnb.2015.64025 Synthesis and Characterization of Fe 3 O 4 Coated on APTES as Carriers for Morin-Anticancer Drug Bassam Saif 1 , Congli Wang 1 , Dong Chuan 2 , Shaomin Shuang 1 1 School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan, China 2 Research Center of Environmental Science and Engineering, Shanxi University, Taiyuan, China Email: smshuang@sxu.edu.cn Received 30 August 2015; accepted 18 October 2015; published 21 October 2015 Copyright © 2015 by authors and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/ Abstract Morin (MR) is an anticancer drug present in fruits and Chinese herbs. Fe 3 O 4 magnetic nanopar- ticles (MNPs) coated on 3-aminopropyl triethoxysilane (APTES) were synthesized (MNPs-APTES) as carriers for MR. The characterization of drug delivery system was confirmed by Fourier Trans- form Infrared (FTIR), Transmission Electron Microscope (TEM), X-Ray Diffraction (XRD), dynamic light scattering (DLS), and vibrating sample magnetometer (VSM). The adsorbed APTES on the magnetite surface (MNPs-APTES) was examined by FTIR. The TEM image showed that the average particle size is obtained to be about 26.7 nm for MNPs-APTES. The MR loading and release beha- vior of MNPs-APTES were studied and the results showed that up to 60% of the adsorbed drug was released within 4 h. In summary, the MNPs-APTES nanocarriers are based on the results, promis- ing for targeted morin drug delivery. Keywords Magnetic Nanoparticles, Drug Delivery, Flavonoid, Morin 1. Introduction With dramatic progress in biomaterials and biomedical applications, huge amount of new and more promising drugs are discovered and designed. Scientists and researchers are now trying to develop mechanisms that allow drugs to go directly to a targeted area of the human body. The success of chemotherapy depends on the drug, its dosage, as well as how it is delivered to its target [1]. Nowadays, nanoparticles (NPs) such as Fe 3 O 4 magnetic nanoparticles (MNPs) have gained significant attention due to their potential biomedical applications such as