Comparison of antiproliferative effect of epigallocatechin gallate when loaded into cationic solid lipid nanoparticles against different cell lines Amélia M. Silva a,b,* , Carlos Martins-Gomes a,b, 1 , Joana F. Fangueiro b,c, 1 , Tatiana Andreani a,b,d , Eliana B. Souto c, e, * a Department of Biology and Environment, University of Trás-os Montes e Alto Douro (UTAD), Quinta de Prados; 5001-801 Vila Real, Portugal b Centre for Research and Technology of Agro-Environmental and Biological Sciences (CITAB-UTAD), Quinta de Prados; 5001-801 Vila Real, Portugal c Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra (FFUC), Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal d Faculty of Sciences, University of Porto (FCUP), Department of Chemistry and Biochemistry, Campo Alegre 4160-007 Porto, Portugal e CEB - Centre of Biological Engineering, University of Minho, Campus de Gualtar 4710- 057 Braga, Portugal 1 Both authors contributed equaly to this work *Corresponding authors Amélia M. Silva Department of Biology and Environment (DeBA); University of Trás-os-Montes and Alto Douro (UTAD); Quinta de Prados; 5001-801 Vila Real; Portugal. Phone: +351 259350106; Fax: +351 259350480; E-mail address: amsilva@utad.pt Eliana B. Souto Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra (FFUC), Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal, Tel.: +351 239 488 400; Fax: +351 239 488 503; E-mail: ebsouto@ff.uc.pt Accepted Manuscript