157 Archives of Orofacial Sciences. 2019; 14(2): 157–168 www.dental.usm.my/aos/  Penerbit Universiti Sains Malaysia. 2019 This work is licensed under the terms of the Creative Commons Attribution (CC BY) (http://creativecommons.org/licenses/by/4.0/). ORIGINAL ARTICLE Volume 14 Issue 2 2019 DOI: 10.21315/aos2019.14.2.394 ARTICLE INFO Submitted: 17/07/2019 Accepted: 18/11/2019 Online: 30/12/2019 To cite this article: Kassim NK, Wan Feun L, Zainuddin SLA, Adnan AS, Ibrahim HA (2019). Oral manifestation and caries experience in pre-dialysis chronic kidney disease patients. Arch Orofac Sci, 14(2): 157–168. https://doi.org/10.21315/aos2019.14.2.394 To link to this article: https://doi.org/10.21315/aos2019.14.2.394 ABSTRACT Patients with chronic kidney disease (CKD) are prone to develop oral lesions due to the disease process or the therapy or both. The systemic problems started to develop in the pre-dialysis stages of CKD. Oral lesions and caries experience are the non-traditional risk factors in progression of CKD. This research was conducted to study and compare the oral manifestation and caries experience of pre-dialysis patients and healthy subjects in Hospital Universiti Sains Malaysia (HUSM). Fifty-eight patients, which consist of 29 pre-dialysis patients and 29 controls were recruited. CKD patients (stage III and IV) who attended nephrology clinic and CKD Resource Centre Unit of HUSM were selected. The control group consisted of healthy patients without any systemic disease who attended dental clinic of HUSM. The patients were examined for the oral manifestation. The decayed, missing, flled teeth (DMFT) index were also recorded. Oral lesions were present in 96.6% of pre-dialysis patients and 51.7% of control group (p < 0.001). The signifcant oral manifestations in pre-dialysis patients were xerostomia, halitosis, abnormal taste, mucosa pallor, enamel hypoplasia, gingival enlargement and abnormal lip pigmentation. There was signifcant difference in caries experience between pre-dialysis patients and healthy controls but no correlation between estimated glomerular fltration rate (eGFR) and caries experience in the pre- dialysis patients. Thus, dental screening needs to be done to control the problems. Future studies with multicentred and larger sample size are warranted to explore the magnitude of this problem. Keywords: Chronic kidney disease; pre-dialysis; oral manifestation; caries experience Oral Manifestation and Caries Experience in Pre- Dialysis Chronic Kidney Disease Patients Nur Karyatee Kassim a,b,d , Loo Wan Feun a,d , Siti Lailatul Akmar Zainuddin a,d , Azreen Syazril Adnan c,d,e , Hanim Afzan Ibrahim a,b,d* a School of Dental Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia b Chemical Pathology Department, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia c Chronic Kidney Disease Resource Centre, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia d Hospital Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia e Management Science University Medical Centre, 40100 Shah Alam, Selangor, Malaysia * Corresponding author: afzankk@usm.my