Note: Within nine months of the publication of the mention of the grant of the European patent in the European Patent Bulletin, any person may give notice to the European Patent Office of opposition to that patent, in accordance with the Implementing Regulations. Notice of opposition shall not be deemed to have been filed until the opposition fee has been paid. (Art. 99(1) European Patent Convention). Printed by Jouve, 75001 PARIS (FR) (19) EP 2 046 802 B1 TEPZZ Z468Z B_T (11) EP 2 046 802 B1 (12) EUROPEAN PATENT SPECIFICATION (45) Date of publication and mention of the grant of the patent: 21.08.2013 Bulletin 2013/34 (21) Application number: 07804590.3 (22) Date of filing: 11.07.2007 (51) Int Cl.: C07D 499/87 (2006.01) C07D 499/21 (2006.01) C07D 499/28 (2006.01) C07D 499/32 (2006.01) A61K 31/431 (2006.01) A61P 31/00 (2006.01) (86) International application number: PCT/IB2007/001941 (87) International publication number: WO 2008/010048 (24.01.2008 Gazette 2008/04) (54) 2-SUBSTITUTED METHYL PENAM DERIVATIVES 2-SUBSTITUIERTE METHYL-PENAM-DERIVATE DÉRIVÉS 2-SUBSTITUÉS DU MÉTHYL PÉNAM (84) Designated Contracting States: AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR (30) Priority: 12.07.2006 IN CH12172006 (43) Date of publication of application: 15.04.2009 Bulletin 2009/16 (73) Proprietor: Allecra Therapeutics GmbH 79539 Lörrach (DE) (72) Inventors: • UDAYAMPALAYAM, Palanisamy, Senthilkumar Chennai, Tamil Nadu 600 119 (IN) • GNANAPRAKASAM, Andrew Chennai, Tamil Nadu 600 119 (IN) • GANAPATHY, Panchapakesan Chennai, Tamil Nadu 600 119 (IN) • MUKUT, Gohain Chennai, Tamil Nadu 600 119 (IN) • VENKATASUBRAMANIAN, Hariharan Chennai, Tamil Nadu 600 119 (IN) • SRIRAM, Rajagopal Chennai, Tamil Nadu 600 119 (IN) • PAUL-SATYASEELA, Maneesh Chennai, Tamil Nadu 600 119 (IN) • SOLANKI, Shakti, Singh Chennai, Tamil Nadu 600 119 (IN) • DEVARAJAN, Sathishkumar Chennai, Tamil Nadu 600 119 (IN) (74) Representative: Murphy, Colm Damien et al Ipulse Carrington House 126-130 Regent Street London W1B 5SE (GB) (56) References cited: EP-A1- 0 097 446 EP-A1- 0 367 124 JP-A- 60 215 688 US-A1- 2005 070 705 US-A1- 2005 228 176 Remarks: The file contains technical information submitted after the application was filed and not included in this specification