Identification of GSK-3 as a potential drug target for epilepsy via bioactivity analysis of the Congolese medicinal plant Indigofera arrecta Najat Aourz 1* , Ann-Sophie K. Serruys 2* , Joëlle Nsimire Chabwine 3 , Pascal Byenda Balegamire 3 , Tatiana Afrikanova 2 , RuAngelie Edrada-Ebel 4 , Alexander I. Grey 4 , Appolinary R. Kamuhabwa 5 , Laura Walrave 1 , Camila V. Esguerra 2 , Fred van Leuven 6 , Peter A. M. de Witte 2 , Ilse Smolders 1$ , Alexander D. Crawford 2$ 1 Center for Neurosciences (C4N), Department of Pharmaceutical Chemistry, Drug Analysis and Drug Information, Vrije Universiteit Brussel, Brussels, Belgium 2 Laboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, University of Leuven, Leuven, Belgium 3 Salama Neuroscience Center, Bukavu, South Kivu, Democratic Republic of the Congo 4 Strathclyde Institute of Pharmacy & Biomedical Sciences, University of Strathclyde, Glasgow, Scotland, UK 5 Department of Pharmacognosy, Muhimbili University of Health & Allied Sciences, Dar es Salaam, Tanzania 6 Department of Human Genetics, Laboratory of Experimental Genetics and Transgenesis/Experimental Genetics Group (LEGTEGG), University of Leuven, Leuven, Belgium * equally contributing first authors $ equally contributing last authors