ACADEMIA Letters A Patient with Anti-LGI1 Related Autoimmune Limbic Encephalitis with Delayed Treatment Muge Sanlier Emine Yaren Yilmaz Baris Kamyab Muhammedrezai Cigdem Turkmen Gulsen Akman Baris Topcular Anti-leucine-rich glioma inactivated- protein 1 limbic encephalitis (LGI1 LE) is a rare neuro- logical disorder characterized by subacute progressive encephalopathy. There is limited data on the efects of treatment timing and clinical outcomes. In this case report, we present a patient with anti-LGI1 LE that had an early diagnosis but delayed treatment and discuss the treatment outcomes. A 65-year-old woman was admitted to our hospital’s neurology clinic 2 years ago with complaints of progressive forgetfulness and behavioral changes. However, soon after the diagnosis of anti-LGI1 related autoimmune limbic encephalitis, the patient refused treatment with intravenous immunoglobulin (IVIg). Two years later, the patient came back to our clinic with slow worsening of her symptoms, and consented to receive treatment this time. Following the treatment with IVIg, her symptoms were dramatically improved. This case demonstrates that it is possible to achieve a good clinical outcome in autoimmune limbic encephalitis patients even with delayed treatment. Academia Letters, May 2021 Corresponding Author: Muge Sanlier, msanlier@hotmail.com Citation: Sanlier, M., Yilmaz, E.Y., Muhammedrezai, B.K., Turkmen , C., Akman, G., Topcular, B. (2021). A Patient with Anti-LGI1 Related Autoimmune Limbic Encephalitis with Delayed Treatment. Academia Letters, Article 774. https://doi.org/10.20935/AL774. 1 ©2021 by the authors — Open Access — Distributed under CC BY 4.0