International Research Journal of Pharmacy and Medical Sciences ISSN (Online): 2581-3277 34 Dewi Puspita Sari, Rezlie Bellatasie, and Ifora Ifora, “Anti-Inflammatory Properties of Coriandrum Sativum L. : A Review,” International Research Journal of Pharmacy and Medical Sciences (IRJPMS), Volume 4, Issue 2, pp. 34-38, 2021. Anti-Inflammatory Properties of Coriandrum Sativum L.: A Review Dewi Puspita Sari, Rezlie Bellatasie, Ifora Ifora* Department of Pharmacology and Clinical Pharmacy, School of Pharmaceutical Science Padang (STIFARM Padang), West Sumatera, Indonesia, 25147 For correspondence; Tel. +(62) 85266031448, Email: iforafo03 @ gmail.com Abstract— Inflammation is a part of the complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. Natural products are a rich source for the discovery of new drugs because of their chemical diversity. The conventional drug available in the market to treat inflammation produces various side-effects. Coriandrum sativum L. is used in many countries as a traditional medicine to treat disorders of the digestive, urinary, and respiratory systems, as well as diabetes, inflammation, and other conditions. however, their important role in anti-inflammatory activity have not been fully explored. The present review is directed towards the compilation of the research articles that have reported on the anti-inflammatory activity of Coriandrum sativum L. A literature review was carried out by searching on the electronic databases including PubMed, ScienceDirect, and Google Scholar for studies pharmacological activities of Coriandrum sativum. All recent research articles published between 2010 and 2020 were included. Based on eligibility criteria, a total of 8 studies were included in this study, consisting of 3 in vitro studies, 5 in vivo studies. The set of pharmacological studies reported evidence of the Coriandrum sativum L. potential for the treatment of diseases associated with an inflammatory response. The Coriandrum sativum L. has been reported to be able to inhibit NO, iNOS, IL-1, IL-6, TNF-α, TNF-R1, ROS, COX-2, NF-kB, MAPK, and reduce edema, as well as exhibited a membrane stabilization effect by inhibiting hypotonicity-induced lysis of erythrocyte membrane. In vitro and in vivo studies strongly demonstrated that Coriandrum sativum has potential as an anti-inflammatory. Keywords— Coriandrum sativum L; Anti-inflammatory; Inflammation; Inflammatory mediator. I. INTRODUCTION nflammation is an important immune response that allows for survival during infection or injury and preserves tissue homeostasis under a variety of noxious conditions. Inflammation comes at the expense of a temporary reduction in the function of the tissue, which can, in turn, lead to the pathogenesis of diseases of altered homeostasis [1]. The progression of degenerative diseases such as rheumatoid arthritis, atherosclerosis, asthma, and other inflammatory diseases is due to chronic inflammation [2]. Medicines that are widely used to reduce inflammation are non-steroidal anti-inflammatory drugs (NSAIDs). The use of NSAIDS usually results in lumen ulceration and intestinal mucosal bleeding [3], [4]. On the other hand, prolonged use of NSAIDs is also associated with severe adverse effects such as gastrointestinal bleeding, and new COX-2 selective drugs do not appear to be risk-free either, as several COX-2 inhibitors are associated with cardiovascular problems [5], [6]. Natural medicines have become increasingly used in recent years as alternative treatments for inflammation because of their relatively minimal side effects [7], [8]. Therefore, there is a strong need for the use of natural products with minimum adverse effects. The previous study showed that the different plants have different therapeutic operations, including anti- inflammatory behaviors [9]–[12]. Coriander (Coriandrum sativum L) belongs to the family Apiaceae and it is an annual and herbaceous plant. Due to its use in the Middle East in all of Southern Asia as well as in most areas of Latin America, Coriander has been named the most widely used flavoring in the world. In addition to its traditional use as a spice and medicine plant, the plant has economic significance because it is used in food goods, perfumes, cosmetics, and soaps as a flavoring agent [13]. Coriandrum sativum L. was shown to contain flavonoids, essential oil, tannins, phenolics, alkaloids, terpenoids, fatty acids, sterols, and glycosides by phytochemical screening. High nutritional values were also included, including proteins, oils, carbohydrates, fibers and a wide variety of minerals, trace elements and vitamins. [14]–[16]. Previous pharmacological studies found that Coriandrum sativum L had antibacterial, antifungal, antioxidant, anti-inflammatory, analgesic, antidiabetic, anti-cancer and several other pharmacological impact [14], [17]–[21]. In this review, we provide an updated review on the anti-inflammatory properties of Coriandrum sativum L. II. METHODS Firstly, the plant name was authenticated using www.theplantlist.org. The present review was based on the data searches conducted in the database of scientific literature, including PubMed, ScienceDirect, and Google Scholar, using the publication from January 2010 to December 2020, using the following keywords: anti-inflammatory, inflammation, Coriandrum sativum. These keywords were used as a guide to search for articles in other databases. All abstracts and full- text articles were collected, examined, summarized, and conclusions made accordingly. The most relevant articles were selected for inclusion in this review. Articles from non-reliable journals/conferences and English and non-English articles which could not be accessed or translated in full were not regarded as exclusion criteria for this study. I