Corrigendum Corrigendum to “Antidepressant effects of sertraline associated with volume increases in dorsolateral prefrontal cortex” [J. Affect. Disord. 146 (2013) 414–419] Ryan Smith a,b,c , Kewei Chen d , Leslie Baxter c , Carolyn Fort a , Richard D. Lane a,b,n a Department of Psychiatry, University of Arizona,1501 N. Campbell Ave., Tucson, AZ 85724-5002, USA b Department of Neuroscience, University of Arizona, Tucson, AZ, USA c Department of Neuroimaging, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ, USA d Department of Neuroimaging, Banner Alzheimer Institute and Banner Good Samaritan PET Center, Phoenix, AZ, USA We recently became aware of a computational error in one of the statistical analyses reported in our paper (Smith et al., 2013) which effectively reversed the direction of our findings. That is, what we reported as gray matter volume increases within subjects in left DLPFC associated with decreasing depression score are actually volume decreases within this area as depressive symptoms improve. We have confirmed that all calculations of statistical significance and other statements in the manuscript are correct. As these findings remain equally significant in relation to depressive symptom improvement, we believe they may still be of clinical interest. In the article we made reference to several previous studies which demonstrate the role of DLPFC in emotion regulation (Ochsner et al., 2002; Ochsner and Gross, 2005; Phillips et al., 2003a), and several others which implicate DLPFC structure and function as being related to depression (Bae et al., 2006; Fales et al., 2009; Koenigs and Grafman, 2009; Phillips et al., 2003b, 2008; Taylor et al., 2004), and we interpreted DLPFC increases as potentially relevant to improved emotion regulation abilities. As our findings actually revealed decreases in DLPFC volume as depression improved, this might be better understood in relation to neuroplasticity-related changes as a result of reductions in bottom-up emotional reactivity. That is, decreases in subcortically-generated negative affective responses might indirectly result in a decreased need for responsivity in regions which are normally engaged to reduce the intensity of such negative emotions. Were this to occur, DLPFC might alter its structure in accordance with this decrease in regulatory demand. Alternatively, it remains possible that these observed structural changes still relate to increases in regulatory ability as we suggested in the original article. It is worth considering that observed changes in gray matter volume are somewhat ambiguous with respect to their underlying causes, and there is no simple mapping between the direction of volume change and reductions/improvements in function. Thus decreases in volume could still reflect adaptive changes in DLPFC circuitry which would allow for more effective emotion regulation abilities. We would like to apologise for any inconvenience caused by our error. References Bae, J.N., MacFall, J.R., Krishnan, K.R., Payne, M.E., Steffens, D.C., Taylor, W.D., 2006. Dorsolateral prefrontal cortex and anterior cingulate cortex white matter alterations in late-life depression. Biol. Psychiatry 60 (12), 1356–1363 (doi:S0006-3223(06)00526-9 [pii] 10.1016/j.biopsych.2006.03.052). Fales, C.L., Barch, D.M., Rundle, M.M., Mintun, M.A., Mathews, J., Snyder, A.Z., Sheline, Y.I., 2009. Antidepressant treatment normalizes hypoactivity in dorsolateral prefrontal cortex during emotional interference processing in major depression. J. Affect. Disord. 112 (1-3), 206–211 (doi:S0165-0327(08)00175-4 [pii] 10.1016/j.jad.2008.04.027). Koenigs, M., Grafman, J., 2009. The functional neuroanatomy of depression: distinct roles for ventromedial and dorsolateral prefrontal cortex. Behav. Brain Res. 201 (2), 239–243 (doi:S0166-4328(09)00150-8 [pii] 10.1016/j.bbr.2009.03.004). Ochsner, K.N., Bunge, S.A., Gross, J.J., Gabrieli, J.D., 2002. Rethinking feelings: an FMRI study of the cognitive regulation of emotion. J. Cogn. Neurosci. 14 (8), 1215–1229, http: //dx.doi.org/10.1162/089892902760807212. Ochsner, K.N., Gross, J.J., 2005. The cognitive control of emotion. Trends Cogn. Sci. 9 (5), 242–249. Phillips, M.L., Drevets, W.C., Rauch, S.L., Lane, R., 2003a. Neurobiology of emotion perception I: the neural basis of normal emotion perception. Biol. Psychiatry 54 (5), 504–514, http://dx.doi.org/10.1016/S0006-3223(03)00168-9. Phillips, M.L., Drevets, W.C., Rauch, S.L., Lane, R., 2003b. Neurobiology of emotion perception II: Implications for major psychiatric disorders. Biol. psychiatry 54 (5), 515–528. Contents lists available at ScienceDirect journal homepage: www.elsevier.com/locate/jad Journal of Affective Disorders http://dx.doi.org/10.1016/j.jad.2014.03.050 0165-0327/& 2014 Elsevier B.V. All rights reserved. DOI of original article: http://dx.doi.org/10.1016/j.jad.2012.07.029 n Corresponding author at: Department of Psychiatry, University of Arizona,1501 N. Campbell Ave., Tucson, AZ 85724-5002, USA. Tel.: þ1 520 626 3272; fax: þ1 520 626 6050. E-mail address: lane@email.arizona.edu (R.D. Lane). Journal of Affective Disorders 162 (2014) 114–115