Revista de Chimie https://revistadechimie.ro https://doi.org/10.37358/Rev.Chim.1949 Rev. Chim., 72(2), 2021, 1 Comparative Study of the Biochemical Response Behavior of Some Highly Toxic Minerals on Selenosis in Rats LOAI ALJERF 1* , MIKE WILLIAMS 2* , ATEM BETHEL AJONG 3 , UKAOGO PRINCE ONYDINMA 4 , FAROUK DEHMCHI 5 , VIET TY PHAM 6 , SUHASINI BHATNAGAR 7 , NASSER BELBOUKHARI 8 1 Key Laboratory of Organic Industries, Department of Chemistry, Faculty of Sciences, Damascus University, Damascus, Syria 2 7101M, USEPA, William Jefferson Clinton Building North (WJC North) 1200 Pennsylvania Avenue N.W. Washington, DC 20004, USA 3 Kekem District Hospital, Kekem, West Region, Cameroon; Department of Biochemistry, University of Dschang, Dschang, West Region, Cameroon 4 Analytical/Environmental Unit, Department of Pure and Industrial Chemistry, Abia State University, Uturu, Nigeria 5 Chemistry Department, Badji Mokhtar University, Annaba, Algeria 6 Faculty of Chemistry, Hue University of Education, 34 Le Loi Str., Hue city, Vietnam 7 Swaroop Enterprises and Biotech Pvt. Ltd., Noida UP, India 8 Bioactive Molecules & Chiral Separation Laboratory, University of TM Bechar, Bechar 08000, Algeria Abstract: Many researchers have studied the metabolism of toxics including selenium (Se) in biological medium in rats and defined some correlations between selenium and other minerals as arsenic (As), cadmium (Cd), mercury (Hg), and thallium (Tl). An investigation of the potential influences of As, Hg, Tl and Pb on Se metabolism, which can suggest new drugs to cope the poisonousness of Se. The current study also has looked into the potential use of As(III)/As(V) toxic in the treatment of essential mineral Se in the animals (as rats) based on sequestration of these toxic elements into biologically inert complexes, reflecting the enormous interest in this subject. The acute studies have been initially achieved by shaping the pulmonary and biliary excretions of the volatile Se in neonatal masculine Holtzman rats which were injected with selenite subcutaneously in the hind flank, then the volatile Se was trapped in 8N HNO3 and the radioselenate detected in a scintillation counter. The chronic cases were carried out with the nursing of rats with a purified diet of water-soluble vitamin mix, fat-soluble vitamin mix, saccharides, oil, and salts. One week after the basic diet, the rats taken Se have received diets containing 10 ppm of the element as sodium selenite (Na2SeO3) or selenate (Na2SeO4) added in the salts. The calorimeter was used to analyze Se in the frozen tissue specimens. As, Hg, and Tl were repressed the volatized Se excreted from the lungs. As has assisted the biliary excretion of Se and inhibited the chronic selenosis. Tl has increased the retention of Se in the liver and kidney, but, had no chronic effect on the amount of Se deposited in all the studied tissues. Similarly, Hg has increased the retention of Se but in the spleen and carcass of rats indicating to the high Se concentration in blood. Hg and Tl have inhibited the Se in urine. No effects of the doses rich in As, Hg, and Tl on the Se excretion in fecal. Even though, we suggest As as a possible medication to chronic selenosis. Keywords: Biological medium, New drug, Poisonousness of Se, Biliary excretion, Tissue, Carcass, Cancer cell 1. Introduction Recently, many countries have posed several legislations [1] and slated very specific strategies [2] in pharmaceutical industry that serve health challenge [3]. However, these created new modifying rules and regulations should control the added ingredients to the drugs including minerals and radioactive materials but in innocuous quantities [1,2]. These supplemented constituents to the pharmaceutical products should be analyzed in reliable analytical procedures [4] which must satisfy the international pharmacological standards [2]. But the problem is that these principles of the aforementioned * email: loai789.aljerf@damascusuniversity.edu.sy