_____________________________________________________________________________________________________ *Corresponding author: E-mail: ajanimustapha@yahoo.com; Asian Journal of Medicine and Health 16(4): 1-7, 2019; Article no.AJMAH.51960 ISSN: 2456-8414 Fracture of the Humeral Bone as the First Clinical Presentation of Metastatic Papillary Thyroid Carcinoma in Ibadan Mustapha Akanji Ajani 1* , Babatope Lanre Awosusi 1 , Ebenezer O. Fatunla 1 , Omolade O. Adegoke 1 and Ayodeji A. Salami 1 1 Department of Pathology, University College Hospital, Ibadan, Nigeria. Authors’ contributions This work was carried out in collaboration among all authors. Author MAA conceived and designed the study. Author BLA wrote the first draft of the manuscript. Authors EOF, OOA and AAS managed the literature searches. Authors MAA and BLA managed the photomicrographs and the literature review. All authors read and approved the final manuscript. Article Information DOI: 10.9734/AJMAH/2019/v16i430149 Editor(s): (1) Dr. William CS Cho, Queen Elizabeth Hospital, Hong Kong, China. Reviewers: (1) Francesca Gorini, National Research Council, Italy. (2) Francesco Pepe, University of Naples Federico II, Italy. (3) Riju Ramachandran, Amrita Vishwa Vidyapeetham University, India. Complete Peer review History: http://www.sdiarticle4.com/review-history/51960 Received 30 July 2019 Accepted 03 October 2019 Published 14 October 2019 ABSTRACT Papillary thyroid carcinoma is the commonest type of thyroid cancer representing 75 to 85 per cent of all thyroid cancer cases. It is often well-differentiated, slow-growing, and localized, although it can metastasize. This is a case of a 49-year-old male who presented with a pathological fracture of the left humerus. A bone biopsy was done at the surgery which had a histological diagnosis of metastatic thyroid carcinoma. A total thyroidectomy was subsequently done and was histologically reported as a follicular variant of papillary thyroid carcinoma. The patient was clinically stable post- thyroidectomy and was discharged home on the 10 th postoperative day and he is currently being followed-up in the surgical outpatient clinic. Pathological fracture as the initial clinical presentation is an unusual manifestation of metastatic thyroid carcinoma; therefore a high index of suspicion is needed to make this diagnosis. In any patient presenting with a pathologic fracture, the possibility of metastatic carcinoma from the thyroid gland should always be considered. Case Study