_____________________________________________________________________________________________________ *Corresponding author: E-mail: ibezute.albert@fupre.edu.ng; Journal of Applied Life Sciences International 17(4): 1-9, 2018; Article no.JALSI.35888 ISSN: 2394-1103 Chemo-therapeutic Potential of Dialium guineense (wild) Leaf Extract on Dumpsite Leachate Induced Hepatoxicity of Wistar Rats Albert C. Ibezute 1* , Sese-Owei A. Ekaye 2 and James E. Onyeukwu 1 1 Department of Environmental Management and Toxicology, College of Sciences, Federal University of Petroleum Resources, P.M.B. 1221, Effurun, Delta State, Nigeria. 2 Department of Animal and Environmental Biology, Faculty of Life Sciences, University of Benin, Benin City, Edo State, Nigeria. Authors’ contributions This work was carried out in collaboration between all authors. Author ACI designed the study, performed the statistical analysis, and wrote the first draft of the manuscript. Author SOAE wrote the protocol and managed the analyses of the study. Author JEO managed the literature searches. All authors read and approved the final manuscript. Article Information DOI: 10.9734/JALSI/2018/35888 Editor(s): (1) Kuldip Singh, Department of Biochemistry, Govt. Medical College, Punjab, India. Reviewers: (1) Muhammad Shahzad Aslam, Universiti Malaysia Perlis, Malaysia. (2) Salwa Refat El-Zayat, Egypt. Complete Peer review History: http://www.sciencedomain.org/review-history/24918 Received 1 st August 2017 Accepted 1 st May 2018 Published 1 st June 2018 ABSTRACT Aims: To investigate the chemo-therapeutic potential of Dailum guineense leaf extract on dumpsite leachate induced hepatoxicity of Wistar rats. Study Design: A Cross-sectional study. Place and Duration of Study: Department of Animal and Environmental Biology (Animal Unit) and Department of Life Science, University of Benin, Benin City, Edo state, Nigeria, between January 2016 and July 2017. Methodology: A total of 20 wistar rats were acclimatized for two weeks and randomly distributed into four groups A to E, and were administered 2ml each different treatment protocol once every 48 hours for 30days.After the exposure period, the surviving rats were examined and sacrificed. Blood and organs were collected for analysis. After which the clinical biochemistry, tissue histology and the expression of some hepatic pro-inflammatory genes were examined. Original Research Article