Journal of Food and Nutrition Research, 2019, Vol. 7, No. 12, 827-835 Available online at http://pubs.sciepub.com/jfnr/7/12/3 Published by Science and Education Publishing DOI:10.12691/jfnr-7-12-3 The Radioprotective and Anticancer Effects of Banana Peels Extract on Male Mice Amaal M. Kamal, Mervat S. Taha, Amr M. Mousa * Department of biological Applications, Nuclear Research Center, Atomic Energy Authority, Egypt *Corresponding author: amr_halim72@yahoo.com Received November 02, 2019; Revised December 03, 2019; Accepted December 13, 2019 Abstract This study was performed to evaluate the radioprotective and anticancer effect of banana peels extract on male mice. Sixty male mice weighted 18-25 gm were used, the animals divided equally into six groups as follow first group act as normal , second group (Tumor control) implanted with Ehrlich tumor, third group ,irradiated group exposed to single dose of 3.0 GY of gamma rays, fourth group (banana peels extract 300 mg/kg/day orally for 3weeks, fifth group (tumor implanted + banana peels extract 300 mg/kg/day orally for 3weeks, sixth group (irradiated with dose 3.0 GY gamma+ 300 mg/kg/day for 3 weeks). At the end of experiment mice were sacrificed by anesthesia and the blood were collected to evaluate biochemical parameters (Complete Blood Count (CBC), Carcino embryonic antigen,(CEA), Malonaldehyde (MDA), Molecular study, electrophoretic assayed. The results showed that banana peels extract ameliorate the alteration in CBC in irradiated and tumor group, and significantly decrease p≤0.05 the elevation of Carcino embryonic antigen in tumor implanted group, significantly decrease the elevation of Malonaldehyde in tumor implanted group and irradiated group. According to protein fractions and western blotting data it could be concluded that, addition banana peels extract consider a crucial impact for Irradiation dose which cleared through huge increase of Polymorphism % for addition banana peels extract (20%) comparing with to Irradiation treatment which didn’t reflect polymorphism. Furthermore, noticeable stimulation for P53 expression level was detected for applying banana peels extract and Irradiation as Compound dosage. Keywords: banana peels extract, antitumor, irradiation protective and mice Cite This Article: Amaal M. Kamal, Mervat S. Taha, and Amr M. Mousa, “The Radioprotective and Anticancer Effects of Banana Peels Extract on Male Mice.” Journal of Food and Nutrition Research, vol. 7, no. 12 (2019): 827-835. doi: 10.12691/jfnr-7-12-3. 1. Introduction Cancer is a multi-factorial disease in the world and economic burden. At all ages, cancer may be affect adults and even fetuses, and the hazard for most varieties increases with age [1]. Cancer causes about 13% of human deaths [2]. Every year about 7.6 million people die from cancer, according to the American Cancer Society [3]. According to World Health Organization, every year more than 10 million new cases of cancer are diagnosed, and in 2020 the statistical tendencies indicate that this number would double [4]. Though there are many therapeutic tactics to treating cancer depend on the toxic compounds. Regrettably, the cytotoxicity properties of most chemotherapy drug is nonspecific and thus don't differentiate between tumor cells and normal healthy cells [5]. In previous years, phenolic compounds derived from natural sources have been found that it possesses antioxidant, anti-inflammatory and has anti-proliferative effects [6]. Banana (Musa species), is one of the important valued plant species which having a number of pharmacological activities [7]. Banana has been considered as one of the antioxidative foods [8]. Ascorbic acid, tocopherol, beta-carotene, phenolic groups, dopamine and gallocatechin had been included in Musa acuminate as antioxidant compounds [9,10]. The banana peels is rich in phytochemical compounds than its pulp [11,12]. Flavonoids and phenols in medicinal plants have a positively role in cancer prevenation through the regulation of genetic pathways without any side effects [13,14]. The mechanistic sides of fruits bioactive constituents may be prevent cancer through various type of action including antioxidant activity. Inhibition of cell proliferation, stimulate of apoptosis, Inhibition of cell invasion and subcellular signaling pathways [15,16]. Protection systems from ionizing radiation are utmost importance in planned and accidental exposures to radiation [17,18]. Improvement of new and effective agents to less radiation hazard using nontoxic radio protectors is considerable interest in defense particularly in radio diagnostics and therapy. Many synthetic and natural compounds have been explored in the recent years for their ability to protect the biological systems against radiations. The aim of the current investigation aimed to study the protective effect of banana peels extracts against gamma radiation and Ehrlich tumor in male mice.