www.ijbcp.com International Journal of Basic & Clinical Pharmacology | July 2019 | Vol 8 | Issue 7 Page 1563 IJBCP International Journal of Basic & Clinical Pharmacology Print ISSN: 2319-2003 | Online ISSN: 2279-0780 Original Research Article A study to evaluate the analgesic activity of Origanum vulgare in mice using hot plate method Siddhi Raveendran, A. V. Tilak, Shraddha Yadav*, Sayan Das, Vishwadeep Madrewar, Vishwanath Kulkarni INTRODUCTION Pain is defined by the International Association for the Study of Pain (IASP) 2011 and the American Pain Society (APS) 2008 as “an unpleasant sensory and emotional experience associated with actual or potential tissue damage or described in terms of such damage.” 1 This definition describes pain as a complex phenomenon with multiple component that impacts a person’s psychological and physiological functioning. 2,3 It is primarily protective in nature but often causes a lot of discomfort. 4 Control of pain is one of the most important therapeutic priority. Analgesia are widely used but of total number of patients who seek treatment of pain, 50% are reported to be dissatisfied with available pharmacological options. 5 In addition, many of these drugs cause serious side effects. Studies have shown that opiates cause physical dependency, tolerance and addiction while NSAIDs usually cause gastrointestinal disorders. 6 ABSTRACT Background: The International Association for Study of pain, has defined pain as actual or potential tissue damage or described in terms of such damage. But the burden of unwanted side effects with current regimens are high. To explore the potential of Ayurveda drugs, this study is done by using Origanum vulgare. Methods: In vivo model used-Hot plate method. Origanum vulgare (84 mg/kg p.o) was administered in mice. The analgesic activity was studied by recording the reaction time after administration of the drug at frequent intervals up to 3 hrs. The results were analysed by ANOVA and Tukey’s test. P value <0.05 was considered as significant. Pentazocine showed statistically prolongation in the reaction time after 30 min as compared to Origanum vulgare. Results: In hot plate method, pentazocine showed statistically significant increase in the reaction time after 30 min of administration as compared to control group. However, Origanum vulgare in a dose of 84 mg/kg showed significantly increase in the reaction time after 30 min of administration as compared to control group. On comparing pentazocine and Origanum vulgare, pentazocine showed highly significant increase in the reaction time after 30 min as compared to Origanum vulgare at 84 mg/kg dose. Conclusions: From the present study, it was concluded that extract of Origanum vulgare exerted analgesic activity in both the models. However, it was less potent than pentazocine. Thus, Origanum vulgare can be used in mild to moderate painful conditions. Keywords: Analgesia, Hot plate method, Origanum vulgare, Pentazocine DOI: http://dx.doi.org/10.18203/2319-2003.ijbcp20192650 Department of Pharmacology, D.Y. Patil medical college, Pimpri, Pune, Maharashtra, India Received: 25 March 2019 Revised: 25 April 2019 Accepted: 07 May 2019 *Correspondence to: Dr. Shraddha Yadav, Email: drshraddha9@gmail.com Copyright: © the author(s), publisher and licensee Medip Academy. This is an open- access article distributed under the terms of the Creative Commons Attribution Non- Commercial License, which permits unrestricted non- commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.