Case Report Clinical and Histopathological Evaluations of Testicular Regression Syn- drome: A Case Report Sabry Nasr Ali* 1, 2 , Amany Mohammed Rabie Mohammed Omar 3,4 , Husam Alhama- dan 5,6 1. Department of Paediatrics, Faculty of Medicine, Minia University, Minia, Egypt 2. Hamad Medical Corporation, Doha, Qatar 3. Department of Pathology, Faculty of Medicine, Minia University, Minia, Egypt 4. Al Emadi Hospital, Doha, Qatar 5. Department of Paediatric Surgery, Pediatric University Hospital, Damascus, Syria 6. Al Emadi Hospital, Doha, Qatar *Correspondence: Dr. Sabry Nasr Ali, Hamad Medical Corporation, Doha, Qatar Tel: +97466130108 Email: sabrynasraly@yahoo.com Received Feb 02, 2020 Accepted Mar 11, 2020 ____________________________________________________________________________________________ Abstract Background: Testicular regression syndrome (TRS) is defined as the partial or total absence of testicular tissue in 46XY patients with normal external genitalia. The incidence of TRS has been reported to be less than 5% in patients with cryptorchidism. Herein, we report a case of a one- year old boy who underwent surgical exploration with an initial diagnosis of cryptorchidism. Case description: a one-year old male came to the outpatient clinic at Al Emadi Hospital, Doha, Qatar. Physical examination revealed normal external genitalia with palpable right testis and non-palpable left testis. The initial diagnosis was cryptorchidism. Testicular structure was not identified and a presumed testicular remnant in the left superficial inguinal ring was sent for histological examination. The histological examination revealed a fibrovascular nodule, spermatic cord structures, calcification and hemosiderin deposits supporting the diagnosis of TRS. Conclusion: When patient fulfills clinical and pathological criteria for TRS, we should consider the possibility of orchiopexy and testicular prosthesis implantation to decrease the risk of testicular torsion and negative psychological effects. KEYWORDS: Testis; Cryptorchidism; Gonadal dysgenesis, Orchiopexy; Histopathology DOI: 1029252/Jcbr.4.2.15 Downloaded from jcbr.goums.ac.ir at 9:34 +0430 on Tuesday June 15th 2021 [ DOI: 10.52547/jcbr.4.2.15 ]