Effects of Vitamin C and E Combination on Element and Oxidative Stress Levels in the Blood of Operative Patients Under Desflurane Anesthesia Berit G. Ceylan & Mustafa Nazıroğlu & A. Cihangir Uğuz & Cihan Barak & Bülent Erdem & Lütfi Yavuz Abstract We investigated effects of vitamin C and E (VCE) administration on desflurane- induced oxidative toxicity and element changes in the blood of operative patients under desflurane general anesthesia. Forty American Society of Anesthesiologists I or II Physical Status adult patients were scheduled for elective surgery. The patients were randomly divided into two groups. Control and VCE group was introduced to anesthesia with desflurane. VCE was administreted to patients in the control and VCE group before 1 hour of anesthesia with desflurane. Baseline (preoperative) and postoperative (at the 1 st , the 24 th , and 72 th h), blood samples were taken from the first and second groups. Erythrocyte and plasma lipid peroxidation levels at the 1 st , 24 th , and 72 th hours were higher in the control than in baseline group, although their levels at the same periods were lower in the VCE group than in the control. Vitamin E levels at the postoperative 1 st and 24 th hours and erythrocyte glutathione peroxidase (GSH-Px) activity at the postoperative 1 st , 24 th , and 72 th hours was lower than in baseline values. Erythrocyte GSH-Px activity and plasma vitamins A, C, and E levels at the postoperative 1 st , 24 th , and 72 th hours were higher in the VCE group than in the control group. Erythrocyte and plasma reduced glutathione, plasma β- carotene, and serum copper, while zinc, selenium, aluminum, iron, magnesium, and calcium levels did not differ between preoperative and postoperative periods in both groups. In DOI 10.1007/s12011-010-8712-3 B. G. Ceylan : B. Erdem : L. Yavuz Department of Anesthesiology and Reanimation, Medical Faculty, Suleyman Demirel University, Isparta, Turkey M. Nazıroğlu (*) : A. C. Uğuz Department of Biophysics, Medical Faculty, Süleyman Demirel University, Morfoloji Binasi, 32260 Isparta, Turkey e-mail: mnaziroglu@med.sdu.edu.tr M. Nazıroğlu Neuroscience Research Center, Suleyman Demirel University, Isparta, Turkey C. Barak Department of Chemistry, Science Institute, Balıkesir University, Balıkesir, Turkey Received: 29 March 2010 / Accepted: 22 April 2010 / Published online: 13 May 2010 # Springer Science+Business Media, LLC 2010 Biol Trace Elem Res (2011) 141:16–25