1 Supplementary Material. The Catalytic Inactivation of the N-half of Human Hexokinase 2 and Structural and Biochemical Characterization of its Mitochondrial Interactions. Mir Hussain Nawaz 1,† , Juliana C. Ferreira 1 , Lyudmila Nedyalkova 2,3 , Haizhong Zhu 2 , César Carrasco-López 1 , Serdal Kirmizialtin 1 , Wael M. Rabeh 1,†,* 1 Science Division, New York University Abu Dhabi, PO Box 129188, Abu Dhabi, United Arab Emirates. 2 Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada. 3 Present address: The Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada. * Corresponding author: wael.rabeh@nyu.edu † These authors contributed equally to this work.