© The Author(s) 2020. Published by Oxford University Press. Page 1 of 4 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. (page number not for citation purposes) Database, 2020, 1–4 doi: 10.1093/database/baaa019 Database tool Database tool Circad: a comprehensive manually curated resource of circular RNA associated with diseases Mercy Rophina 1,† , Disha Sharma 1,2,† , Mukta Poojary 1,2 and Vinod Scaria 1,2, * 1 Genome Informatics Department, CSIR-Institute of Genomics and Integrative Biology, Mathura Road, District-South Delhi, New Delhi-110025, India and 2 Academy of Scientific and Innovative Research (AcSIR), AcSIR headquarters, CSIR-HRDC campus, Postal Staff College Area, Sector 19, Kamla Nehru Nagar, Ghaziabad, Uttar Pradesh -201002, India *Corresponding author: Genome Informatics Department, CSIR-Institute of Genomics and Integrative Biology, Mathura Road, District- South Delhi, New Delhi-110025. Tel: +91-1125895615; Fax: +91-1127667471; Email: vinods@igib.in † Contributed equally and would like to be known as joint first authors. Citation details: Rophina,M., Sharma,D., Poojary,M. et al. Circad: a comprehensive manually curated resource of circular RNA associated with diseases. Database (2020) Vol. 2020: article ID baaa019; doi:10.1093/database/baaa019 Received 24 July 2019; Revised 22 January 2020; Accepted 17 February 2020 Abstract Circular RNAs (circRNAs) are unique transcript isoforms characterized by back splicing of exon ends to form a covalently closed loop or circular conformation. These transcript isoforms are now known to be expressed in a variety of organisms across the kingdoms of life. Recent studies have shown the role of circRNAs in a number of diseases and increasing evidence points to their potential application as biomarkers in these diseases. We have created a comprehensive manually curated database of circular RNAs asso- ciated with diseases. This database is available at URL http://clingen.igib.res.in/circad/. The Database lists more than 1300 circRNAs associated with 150 diseases and mapping to 113 International Statistical Classification of Diseases (ICD) codes with evidence of association linked to published literature. The database is unique in many ways. Firstly, it provides ready-to-use primers to work with, in order to use circRNAs as biomarkers or to perform functional studies. It additionally lists the assay and PCR primer details including experimentally validated ones as a ready reference to researchers along with fold change and statistical significance. It also provides standard disease nomenclature as per the ICD codes. To the best of our knowledge, circad is the most comprehensive and updated database of disease associated circular RNAs. Availability: http://clingen.igib.res.in/circad/ Downloaded from https://academic.oup.com/database/article/doi/10.1093/database/baaa019/5812714 by guest on 30 June 2021